Immunization with the Recombinant Cholera Toxin B Fused to Fimbria 2 Protein Protects against Bordetella pertussis Infection
Figure 3
Protective capacity of CTB-Fim2. Groups of animals were immunized (a) intraperitoneally or (b) intranasally three times with PBS, CTB (IN only), rFim2, BpFim2, or CTB-Fim2 every 12 days followed by IN challenge with UFC of the Tohama I strain of B. pertussis. At 8 days postinfection, animals were killed and lung samples were collected for UFC counting. Each point represents the mean (± standard error) of 8 animals ( versus PBS; versus PBS, CTB, and rFim2).
