Identification of a 20-Gene Expression-Based Risk Score as a Predictor of Clinical Outcome in Chronic Lymphocytic Leukemia Patients

Table 2

Cox univariate and multivariate analysis of OS in CLL patient’s training cohort (𝑛=107).

(a)

Prognostic variable	Overall survival
	(𝑛=107)
	HR	𝑃 value
GEP risk score	45.39	<0.0001
ADAM29	0.40	0.04
AKAP12	2.60	0.02
DMD	3.39	0.004
LPL	4.19	0.001
NRIP1	0.12	<0.0001
SEPT10	2.95	0.01
SPG20	0.28	0.006
TCF7	0.35	<0.0001
TCL1A	4.14	0.001
TPM1	2.50	0.02
ZAP70	3.28	0.02
PS8	10.40	<0.0001
Del(17p)	10.13	<0.0001

(b)

Prognostic variables compared two by two	Overall survival
	(𝑛=107)
	HR	𝑃 value
GEP risk score	55.30	<0.0001
ADAM29	1.63	NS
GEP risk score	46.71	<0.0001
AKAP12	0.93	NS
GEP risk score	51.78	<0.0001
DMD	0.75	NS
GEP risk score	40.52	<0.0001
LPL	1.49	NS
GEP risk score	8.29	<0.0001
NRIP1	0.035	0.003
GEP risk score	50.95	<0.0001
SEPT10	0.76	NS
GEP risk score	53.31	<0.0001
SPG20	0.20	0.001
GEP risk score	28.34	<0.0001
TCF7	0.067	0.001
GEP risk score	40.39	<0.0001
TCL1A	2.33	NS
GEP risk score	69.60	<0.0001
TPM1	4.77	0.001
GEP risk score	44.60	<0.0001
ZAP70	1.04	NS
GEP risk score	10.35	<0.0001
PS8	4.73	0.001
GEP risk score	38.95	<0.0001
Del(17p)	3.14	0.02

(c)

All prognostic variables	Overall survival
	(𝑛=107)
	HR	𝑃 value
GEP risk score	26.23	0.002
ADAM29	1.04	NS
AKAP12	6.89	NS
DMD	0.58	NS
LPL	0.54	NS
NRIP1	0.017	0.01
SEPT10	0.58	NS
SPG20	0.76	NS
TCF7	0.022	0.01
TCL1A	0.29	NS
TPM1	2.83	NS
ZAP70	1.53	NS
PS8	0.63	NS
Del(17p)	1.94	NS

The prognostic factors were tested as single variable (a) or multivariables (b,c) using Cox-model. 𝑃 values and the hazard ratios (HR) are shown. NS: not significant at a 5% threshold.