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BioMed Research International
Volume 2014 (2014), Article ID 424767, 20 pages
Research Article

α-Actinin TvACTN3 of Trichomonas vaginalis Is an RNA-Binding Protein That Could Participate in Its Posttranscriptional Iron Regulatory Mechanism

Departamento de Infectómica y Patogénesis Molecular, Centro de Investigación y de Estudios Avanzados del IPN (CINVESTAV-IPN), 07360 México, DF, Mexico

Received 9 September 2013; Accepted 24 November 2013; Published 2 March 2014

Academic Editor: Wanderley De Souza

Copyright © 2014 Jaeson Santos Calla-Choque et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

In this figure we show a multiple alignment of the amino acid deduced sequence of the five actinin genes found in the T. vaginalis genome [8] (TvACTN1, TvACTN2, TvACTN3, TvACTN4, and TvACTN5). These α-actinin proteins have different sizes (609, 931, 1129, 1137, and 1271 amino acid [aa] residues) and different identities compared with TvACTN3 (55.19, 53.25, 22.1, and 15.56% with TvACTN1, TvACTN2, TvACTN4, and TvACTN5, respectively). The most conserved region among them is the N-terminal corresponding to the actin-binding domain. The most divergent region is the central domain that contains the spectrin repeats (Please see Figure 3).

  1. Supplementary Figure