Proteomic Study of HPV-Positive Head and Neck Cancers: Preliminary Results

Table 3

Proteins with decreased and increased abundance between the HPV− cell line and the HPV+ cell lines.

Accession number	𝑃 value	Fold change	Protein name	Number of peptide identified (95%)
tr∣D3DWI6∣D3DWI6_HUMAN	0.007	0.007	Prostate stem cell antigen	1
tr∣Q6LES2∣Q6LES2_HUMAN	0.000005	0.045	ANXA4 protein	22
tr∣B3KY42∣B3KY42_HUMAN	0.001	0.062	cDNA FLJ46788 fis, clone TRACH3028855, highly similar to Pseudouridylate synthase 7	1
tr∣B4E2Q6∣B4E2Q6_HUMAN	0.003	0.093	Regulation of nuclear pre-mRNA domain-containing protein 2	2
tr∣F8WE04∣F8WE04_HUMAN	0.00156	0.111	Heat shock protein beta-1	54
tr∣Q59GW6∣Q59GW6_HUMAN	0.00375	0.134	Acetyl-CoA acetyltransferase, cytosolic variant	20
tr∣B7Z992∣B7Z992_HUMAN	0.00369	0.137	cDNA FLJ53698, highly similar to Gelsolin	39
tr∣A8K287∣A8K287_HUMAN	0.00793	0.143	Synaptosomal-associated protein	1
tr∣A8K5J7∣A8K5J7_HUMAN	0.00757	0.150	cDNA FLJ77290, highly similar to Homo sapiens BCL2-associated athanogene 5	1
tr∣B2R4I8∣B2R4I8_HUMAN	0.00098	0.159	cDNA, FLJ92106, highly similar to Homo sapiens adaptor-related protein complex 3, sigma 1 subunit(AP3S1),	2
tr∣E9PPU0∣E9PPU0_HUMAN	0.00505	0.168	Epiplakin	97
tr∣B7Z6B8∣B7Z6B8_HUMAN	0.00178	0.171	2,4-dienoyl-CoA reductase, mitochondrial	10
tr∣Q6NVI1∣Q6NVI1_HUMAN	0.00008	0.197	MARCKS protein	26
tr∣C9JEJ2∣C9JEJ2_HUMAN	0.00782	0.199	Choline-phosphate cytidylyltransferase A	15
tr∣Q9BRV4∣Q9BRV4_HUMAN	0.00187	0.202	Vesicle-associated membrane protein 3 (Cellubrevin)	3
tr∣B2RCZ7∣B2RCZ7_HUMAN	0.00005	0.204	Ethylmalonic encephalopathy 1, isoform CRA_a	18
tr∣B4DL87∣B4DL87_HUMAN	0.00444	0.206	cDNA FLJ52243, highly similar to Heat-shock protein beta-1	70
tr∣B7WPG3∣B7WPG3_HUMAN	0.00444	0.208	Heterogeneous nuclear ribonucleoprotein L-like	1
tr∣Q6IAX6∣Q6IAX6_HUMAN	0.00052	0.213	3′-phosphoadenosine 5′-phosphosulfate synthase 1 OS	1
tr∣E7EMB1∣E7EMB1_HUMAN	0.00413	0.227	Switch-associated protein 70	9
tr∣E9PMV1∣E9PMV1_HUMAN	0.00202	0.238	Plectin	10
tr∣F5GXF7∣F5GXF7_HUMAN	0.00479	0.252	Zinc finger protein 185	16
tr∣E5RJR5∣E5RJR5_HUMAN	0.00022	0.252	S-phase kinase-associated protein 1	4
tr∣E7ESP4∣E7ESP4_HUMAN	0.00135	0.259	Integrin alpha-2	12
tr∣Q96IF9∣Q96IF9_HUMAN	0.00454	0.273	VCP protein	112
tr∣F8W785∣F8W785_HUMAN	0.00221	0.276	Golgi integral membrane protein 4	1
tr∣B7Z5V6∣B7Z5V6_HUMAN	0.00881	0.278	cDNA FLJ57046, highly similar to Lysosomal alpha-glucosidase	4
tr∣A6NEL0∣A6NEL0_HUMAN	0.00582	0.279	Non-histone chromosomal protein HMG-14	19
tr∣G0TQY6∣G0TQY6_HUMAN	0.00471	0.281	Lutheran blood group	19
tr∣A8K4W6∣A8K4W6_HUMAN	0.00045	0.287	Phosphoglycerate kinase	123
tr∣Q53RU4∣Q53RU4_HUMAN	0.00154	0.292	Putative uncharacterized protein MSH2	4
tr∣A8K2Y9∣A8K2Y9_HUMAN	0.0011	0.308	6-phosphogluconate dehydrogenase, decarboxylating	33
tr∣B3KMV5∣B3KMV5_HUMAN	0.00078	0.319	cDNA FLJ12728 fis, clone NT2RP2000040, highly similar to Protein FAM62A	9
tr∣B3KMN7∣B3KMN7_HUMAN	0.00131	0.320	cDNA FLJ11717 fis, clone HEMBA1005241	5
tr∣B4DN60∣B4DN60_HUMAN	0.00015	0.323	Asparagine-tRNA ligase, cytoplasmic	10
tr∣B1ANK7∣B1ANK7_HUMAN	0.00465	0.347	Fumarate hydratase	19
tr∣Q0VDC6∣Q0VDC6_HUMAN	0.00257	0.357	FKBP1A protein	9
tr∣C8KIL8∣C8KIL8_HUMAN	0.00769	0.368	Glutathione reductase delta8 alternative splicing variant	1
tr∣B4DUK1∣B4DUK1_HUMAN	0.00161	0.375	cDNA FLJ51310, moderately similar to Peroxiredoxin-6	10
tr∣E9PP14∣E9PP14_HUMAN	0.00564	0.383	GDP-L-fucose synthase	1
tr∣D6RE99∣D6RE99_HUMAN	0.00776	0.399	Histidine triad nucleotide-binding protein 1	8
tr∣B1AKP7∣B1AKP7_HUMAN	0.00099	0.403	TAR DNA binding protein	11
tr∣Q6FHQ6∣Q6FHQ6_HUMAN	0.00442	0.418	IDH1 protein	21
tr∣A8K4I2∣A8K4I2_HUMAN	0.00771	0.421	Histone 1, H1c	123
tr∣A0PK02∣A0PK02_HUMAN	0.00526	0.424	PLXNB2 protein	3
tr∣Q6IAW5∣Q6IAW5_HUMAN	0.00939	0.446	CALU protein	22
tr∣Q6ZNW0∣Q6ZNW0_HUMAN	0.0098	0.449	cDNA FLJ27036 fis, clone SLV08019, highly similar to Homo sapiens stomatin (EPB72)-like 2 (STOML2)	10
tr∣A4UCS8∣A4UCS8_HUMAN	0.00267	0.455	Enolase	130
tr∣Q5TZZ9∣Q5TZZ9_HUMAN	0.00184	0.461	ANXA1 protein	96
tr∣E2DRY6∣E2DRY6_HUMAN	0.00118	0.504	Enolase	217
tr∣A4D105∣A4D105_HUMAN	0.00122	0.514	Replication protein A3, 14 kDa	7
tr∣Q5TCI8∣Q5TCI8_HUMAN	0.00168	0.530	Lamin A/C	119
tr∣B2R5W3∣B2R5W3_HUMAN	0.00065	0.566	cDNA, FLJ92658, highly similar to Homo sapiens poly (ADP-ribose) polymerase family, member 1 (PARP1)	51
tr∣B4E0E1∣B4E0E1_HUMAN	0.00065	0.566	cDNA FLJ53442, highly similar to Poly (ADP-ribose) polymerase 1	52
tr∣D6W5C0∣D6W5C0_HUMAN	0.0096	0.608	Spectrin, beta, nonerythrocytic 1, isoform CRA_b	39
tr∣E9KL44∣E9KL44_HUMAN	0.00912	0.646	Epididymis tissue sperm binding protein	39
tr∣B7Z6F8∣B7Z6F8_HUMAN	0.00713	1.244	Clathrin interactor 1	6
tr∣A8K7A4∣A8K7A4_HUMAN	0.00524	1.414	cDNA FLJ76904, highly similar to Homo sapiens methionine adenosyltransferase II, beta (MAT2B)	12
tr∣F8WDI0∣F8WDI0_HUMAN	0.00874	1.505	Ubiquitin-like-conjugating enzyme ATG3	2
tr∣B3KRT1∣B3KRT1_HUMAN	0.00437	1.706	Inositol-3-phosphate synthase 1	11
tr∣Q6PK50∣Q6PK50_HUMAN	0.0069	1.788	HSP90AB1 protein	65
tr∣Q6NVC0∣Q6NVC0_HUMAN	0.00315	1.80	SLC25A5 protein	37
tr∣E5RH41∣E5RH41_HUMAN	0.00169	1.848	Transcription initiation factor IIE subunit beta	1
tr∣B4DYH1∣B4DYH1_HUMAN	0.00023	1.878	Heat shock 105 kDa/110 kDa protein 1, isoform CRA_b	52
tr∣E9PQI8∣E9PQI8_HUMAN	0.00195	1.888	U4/U6.U5 tri-snRNP-associated protein 1	3
tr∣B5BTY7∣B5BTY7_HUMAN	0.00798	1.966	T-complex protein 1 subunit beta	46
tr∣B4DUG4∣B4DUG4_HUMAN	0.00275	1.975	cDNA FLJ51308	1
tr∣B3KTJ9∣B3KTJ9_HUMAN	0.00804	1.975	cDNA FLJ38393 fis, clone FEBRA2007212	15
tr∣D6R938∣D6R938_HUMAN	0.00024	1.986	Calcium/calmodulin-dependent protein kinase (CaM kinase) II delta	2
tr∣A8K259∣A8K259_HUMAN	0.00046	2.070	cDNA FLJ78501, highly similar to Homo sapiens serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) (SERPINH1)	18
tr∣Q54A51∣Q54A51_HUMAN	0.00291	2.079	Basigin (Ok blood group), isoform CRA_a	20
tr∣Q6IPH7∣Q6IPH7_HUMAN	0.00287	2.131	RPL14 protein	19
tr∣A8K9U6∣A8K9U6_HUMAN	0.00504	2.132	cDNA FLJ76121, highly similar to Homo sapiens zinc finger CCCH-type, antiviral 1 (ZC3HAV1)	7
tr∣D3DPU2∣D3DPU2_HUMAN	0.00049	2.135	Adenylyl cyclase-associated protein	59
tr∣B3KN49∣B3KN49_HUMAN	0.00667	2.165	cDNA FLJ13562 fis, clone PLACE1008080, highly similar to Homo sapiens hexamethylene bis-acetamide inducible 1 (HEXIM1)	6
tr∣E9PR70∣E9PR70_HUMAN	0.0005	2.167	Serpin H1	17
tr∣Q05D43∣Q05D43_HUMAN	0.00597	2.195	YBX1 protein	25
tr∣E7EQV9∣E7EQV9_HUMAN	0.00711	2.247	Ribosomal protein L15	5
tr∣A8K2Q6∣A8K2Q6_HUMAN	0.00501	2.278	Peptidyl-prolyl cis-trans isomerase	3
tr∣Q05CM9∣Q05CM9_HUMAN	0.000005	2.287	PSIP1 protein	18
tr∣Q7L7Q6∣Q7L7Q6_HUMAN	0.00109	2.321	RTN4	6
tr∣Q5U077∣Q5U077_HUMAN	0.00247	2.379	L-lactate dehydrogenase	38
tr∣F5GZA8∣F5GZA8_HUMAN	0.00582	2.384	SH3 domain-binding protein 1	6
tr∣E7EPK6∣E7EPK6_HUMAN	0.00396	2.394	40S ribosomal protein S24	7
tr∣Q8TBR3∣Q8TBR3_HUMAN	0.00685	2.414	Fusion (Involved in t(12;16) in malignant liposarcoma)	33
tr∣A8MX94∣A8MX94_HUMAN	0.00964	2.475	Glutathione S-transferase P	50
tr∣B4DUI3∣B4DUI3_HUMAN	0.00619	2.484	Eukaryotic translation initiation factor 3 subunit J	10
tr∣Q6P1N4∣Q6P1N4_HUMAN	0.00019	2.492	IQGAP1 protein	64
tr∣A4QPB0∣A4QPB0_HUMAN	0.00019	2.492	IQ motif containing GTPase activating protein 1	83
tr∣B7ZBH1∣B7ZBH1_HUMAN	0.00876	2.499	Eukaryotic translation initiation factor 6	9
tr∣B4DZI8∣B4DZI8_HUMAN	0.00931	2.525	Coatomer protein complex, subunit beta 2	8
tr∣B4DWA0∣B4DWA0_HUMAN	0.00454	2.535	cDNA FLJ54188, moderately similar to High mobility group protein HMG-I/HMG-Y	8
tr∣B4DY28∣B4DY28_HUMAN	0.0063	2.556	cDNA FLJ61189, highly similar to Cysteine and glycine-rich protein 1	2
tr∣B7Z921∣B7Z921_HUMAN	0.00179	2.601	cDNA FLJ61669, highly similar to Transcription elongation regulator 1	5
tr∣Q8NF45∣Q8NF45_HUMAN	0.00368	2.657	FLJ00353 protein	8
tr∣F8WEE0∣F8WEE0_HUMAN	0.00313	2.672	Protein NDRG1	1
tr∣E9PIM9∣E9PIM9_HUMAN	0.00026	2.676	Ribonuclease H1	24
tr∣B4E2D3∣B4E2D3_HUMAN	0.00154	2.685	Nuclear pore complex protein Nup50	4
tr∣Q6FI03∣Q6FI03_HUMAN	0.00472	2.715	G3BP protein	27
tr∣B7Z7L3∣B7Z7L3_HUMAN	0.00077	2.752	NADH-cytochrome b5 reductase 3	10
tr∣B1AH89∣B1AH89_HUMAN	0.00436	2.775	Tubulin tyrosine ligase-like family, member 12	14
tr∣Q6IBT3∣Q6IBT3_HUMAN	0.00347	2.783	CCT7 protein	37
tr∣Q53HV2∣Q53HV2_HUMAN	0.00347	2.783	Chaperonin containing TCP1, subunit 7 (Eta) variant	45
tr∣Q5W0H4∣Q5W0H4_HUMAN	0.00403	2.793	Tumor protein, translationally controlled 1	13
tr∣B4DZX7∣B4DZX7_HUMAN	0.00318	2.817	Thioredoxin domain containing, isoform CRA_b	1
tr∣B3KRA1∣B3KRA1_HUMAN	0.00016	2.844	cDNA FLJ33914 fis, clone CTONG2016575, highly similar to SON PROTEIN	3
tr∣B7Z8R6∣B7Z8R6_HUMAN	0.00049	2.846	cDNA FLJ51445, highly similar to AMBP protein	1
tr∣Q6IAX2∣Q6IAX2_HUMAN	0.0057	2.852	RPL21 protein	13
tr∣B2R4F3∣B2R4F3_HUMAN	0.00842	2.868	cDNA, FLJ92068, highly similar to Homo sapiens Rho GDP dissociation inhibitor (GDI) beta (ARHGDIB)	3
tr∣D3DQ70∣D3DQ70_HUMAN	0.00312	2.882	SERPINE1 mRNA binding protein 1, isoform CRA_d	15
tr∣E7ERF4∣E7ERF4_HUMAN	0.00326	2.973	Adenylosuccinate lyase	10
tr∣B2RAU8∣B2RAU8_HUMAN	0.00573	3.071	cDNA, FLJ95131, highly similar to Homo sapiens nucleolar and coiled-body phosphoprotein 1 (NOLC1)	11
tr∣B4DIT0∣B4DIT0_HUMAN	0.00069	3.098	Anion exchange protein 2	2
tr∣B5MCA4∣B5MCA4_HUMAN	0.00511	3.111	Epithelial cell adhesion molecule	4
tr∣Q6GMS8∣Q6GMS8_HUMAN	0.00075	3.140	Syntaxin-16	2
tr∣B3KN82∣B3KN82_HUMAN	0.00899	3.209	cDNA FLJ13913 fis, clone Y79AA1000231, highly similar to Nucleolar protein NOP5	12
tr∣B4E0L0∣B4E0L0_HUMAN	0.00362	3.211	cDNA FLJ54030, highly similar to Polymerase delta-interacting protein 3	9
tr∣D3DSF7∣D3DSF7_HUMAN	0.00302	3.236	SON DNA binding protein, isoform CRA_b	7
tr∣F8VVL1∣F8VVL1_HUMAN	0.00199	3.278	Density-regulated protein	6
tr∣A8K787∣A8K787_HUMAN	0.0069	3.285	cDNA FLJ75273, highly similar to Homo sapiens solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4	17
tr∣B4DSL9∣B4DSL9_HUMAN	0.00403	3.297	cDNA FLJ58748, highly similar to U3 small nucleolar RNA-associated protein 6homolog	2
tr∣B3KWL6∣B3KWL6_HUMAN	0.00036	3.382	Methionine aminopeptidase	7
tr∣B3KPR5∣B3KPR5_HUMAN	0.00165	3.421	cDNA FLJ32094 fis, clone OCBBF2000986, highly similar to Homo sapiens elongation factor Tu GTP binding domain containing 1, transcript variant 1	1
tr∣Q14222∣Q14222_HUMAN	0.00673	3.562	EEF1A protein	108
tr∣Q16577∣Q16577_HUMAN	0.00673	3.562	Elongation factor 1-alpha	143
tr∣Q53H88∣Q53H88_HUMAN	0.0034	3.579	Dynactin 2 variant	7
tr∣Q59GP5∣Q59GP5_HUMAN	0.00198	3.601	Eukaryotic translation elongation factor 1 alpha 2 variant	45
tr∣Q68CS0∣Q68CS0_HUMAN	0.00079	3.630	Ornithine aminotransferase, mitochondrial	7
tr∣F5GXR3∣F5GXR3_HUMAN	0.00387	3.972	Parathymosin	1
tr∣F5H8L6∣F5H8L6_HUMAN	0.00141	3.996	Dipeptidyl peptidase 3	17
tr∣Q6IPS9∣Q6IPS9_HUMAN	0.00459	4.001	Elongation factor 1-alpha	311
tr∣F8W940∣F8W940_HUMAN	0.00537	4.120	CUGBP Elav-like family member 1	3
tr∣B7ZLC9∣B7ZLC9_HUMAN	0.00416	4.234	GEMIN5 protein	3
tr∣Q6FIG4∣Q6FIG4_HUMAN	0.00017	4.372	RAB1B protein	19
tr∣F5H4R6∣F5H4R6_HUMAN	0.00067	4.373	Nucleosome assembly protein 1-like 1	32
tr∣Q6PK82∣Q6PK82_HUMAN	0.00008	4.425	AP3D1 protein	5
tr∣B3KW52∣B3KW52_HUMAN	0.0073	4.443	cDNA FLJ42145 fis, clone TESTI4000228, highly similar to Mus musculus ubiquitin family domain containing 1 (Ubfd1), mRNA	2
tr∣E9PS95∣E9PS95_HUMAN	0.00885	4.636	Mitochondrial glutamate carrier 1	1
tr∣Q6FH57∣Q6FH57_HUMAN	0.00045	4.653	Peptidyl-prolyl cis-trans isomerase	4
tr∣B3KN79∣B3KN79_HUMAN	0.00107	4.681	cDNA FLJ13894 fis, clone THYRO1001671, highly similar to 59 kDa 2′-5′-oligoadenylate synthetase-like protein	3
tr∣Q53GW1∣Q53GW1_HUMAN	0.00487	4.697	Vesicle transport-related protein isoform a variant (Fragment)	3
tr∣Q5U0I6∣Q5U0I6_HUMAN	0.00098	4.810	RAB1A protein	14
tr∣Q5TBU5∣Q5TBU5_HUMAN	0.00439	5.144	Adipose specific 2	1
tr∣E9PK25∣E9PK25_HUMAN	0.000007	6.239	Cofilin-1	96
tr∣F8W7I9∣F8W7I9_HUMAN	0.00003	6.928	Ran GTPase-activating protein 1	15
tr∣B3KU10∣B3KU10_HUMAN	0.00049	7.509	Interferon-induced GTP-binding protein Mx1	22
tr∣Q75MY7∣Q75MY7_HUMAN	0.0005	7.948	MX2	11
tr∣D2KFR9∣D2KFR9_HUMAN	0.00057	8.090	Signal transducer and activator of transcription 1-alpha/beta	3
tr∣E9PCQ3∣E9PCQ3_HUMAN	0.00031	8.511	Ubiquitin carboxyl-terminal hydrolase	1
tr∣B4DTE6∣B4DTE6_HUMAN	0.0066	8.644	cDNA FLJ56243, highly similar to Melanoma-associated antigen 4	6
tr∣Q8IV97∣Q8IV97_HUMAN	0.00356	10.882	Solute carrier family 7 (Cationic amino acid transporter, y+ system), member 5	3
tr∣Q96J85∣Q96J85_HUMAN	0.00055	14.133	C-Mpl binding protein	1
tr∣F5H667∣F5H667_HUMAN	0.00003	16.263	Aspartyl/asparaginyl beta-hydroxylase	4
tr∣A5GZA6∣A5GZA6_HUMAN	0.000002	53.611	Cysteine-rich with EGF-like domain protein 2	2
tr∣B4DZM8∣B4DZM8_HUMAN	0.00002	145.941	26S proteasome non-ATPase regulatory subunit 5	2