RNA Sequencing Reveals Upregulation of RUNX1-RUNX1T1 Gene Signatures in Clear Cell Renal Cell Carcinoma
Figure 1
RUNX1-RUNX1T1 signature was upregulated in ccRCC. (a) PGSEA score from microarray data comprising 90 tumor and 13 normal tissues shows RUNX1-RUNX1T1 signature is up-regulated in ccRCC and shows no correlation to tumor grade. (b) Hypoxia related signature was specifically upregulated in ccRCC, and no significant upregulation was found in other kinds of RCC; (c) RUNX1-RUNXT1 related signature was specifically upregulated in ccRCC, and no significant upregulation was found in other kinds of RCC; (d) kidney function related signature was downregulated among all subtypes of RCC. N, normal samples; G1, tumor grade1; G2, tumor grade1; G3, tumor grade4; CC: clear cell; CHR: chromophobe; ON: oncocytoma; P: papillary; WM: Wilms’ tumor.
