MicroRNA Expression Profiling Altered by Variant Dosage of Radiation Exposure

Table 2

Putative and validated interactions between the differentially expressed microRNAs and gene candidates specific to each dose of ⁶⁰Co radiation.

Dose (Gy)	miRNA	Fold change	Target gene	Fold change
0.5	hsa-miR-185-5p	1.18	TNFSF10^a	−1.21
			GLUL^c	−1.49
1	hsa-miR-107	1.09	14 genes^c	Decreased
	hsa-miR-144	1.60	SELL	−1.04
			COTL	−1.06
			CEP63	−1.14
	hsa-miR-17-5p	1.09	MCL1^a	−1.26
			FGL2^b	−1.33
			30 other genes^c	Decreased
	hsa-miR-185-5p	1.01	32 genes^c	Decreased
	hsa-miR-20b-5p	1.01	27 genes^c	Decreased
5	hsa-miR-142-3p	−1.02	MAP4K3^b	1.32
			DIRC2^b	1.01
			TIPARP^b	1.05
			PDE4B^c	1.54
	hsa-miR-142-5p	−1.09	AHR^a	1.31
			SLC36A4^b	1.11
	hsa-miR-223-3p	−1.27	DUSP10^b,c	1.07
			EFNA1^b	1.01
	hsa-miR-451a	−1.28	SLC7A11^c	1.14

Experimentally validated miRNA-gene interaction as identified by miRWalk.
^bmiRNA-gene interaction predicted by at least four out of the five selected miRNA target prediction databases.
^cmiRNA-gene interaction predicted by miRTar; the complete gene list is provided in Supplementary Material 1 (see Supplementary Material available online at http://dx.doi.org/10.1155/2014/456323).