Human Pharmacokinetics of High Dose Oral Curcumin and Its Effect on Heme Oxygenase-1 Expression in Healthy Male Subjects

Table 1

Baseline characteristics.

Baseline characteristics	S/S (𝑛=5)	L/L (𝑛=5)
(GT)n repeats	23.4±1.07	31.5±2.92
Age (years)	29.4±3.71	27±3.94
Weight (kg)	81.6±9.47	80.4±11.19
BMI (kg/m^2)	23.68±1.98	23.68±1.75
Conjugated bilirubin (mg/dL)*	0.15±0.03	0.195±0.08
Unconjugated bilirubin (mg/dL)	0.76±0.21	0.71±0.27
HO-1 mRNA (ΔCT)	4.31±1.25	4.38±1.15
HO-1 protein (HO-1/𝛽-actin)	0.13±0.15	0.13±0.14

Baseline characteristics of the S/S and L/L groups. Data are presented as means ± SD. Significant statistical differences are reported in the text (^∗𝑃=0.015). (GT)n repeats: GT length polymorphism; BMI: body mass index; HO-1 mRNA (ΔCT): HO-1 mRNA level as cycle threshold difference compared to the reference gene (18S).