In Vitro Antioxidant, Antibacterial, and Cytotoxic Activity and In Vivo Effect of Syngonium podophyllum and Eichhornia crassipes Leaf Extracts on Isoniazid Induced Oxidative Stress and Hepatic Markers

Table 2

Effect of S. podophyllum and E. crassipes leaf aqueous extracts on isoniazid induced alterations of serum markers in Wistar rats.

Parameters	Control	INH	INH + L52	INH + SP	INH + EC
CRE mg/dL	0.353 ± 0.11	1.830 ± 0.06***	0.550 ± 0.19^#	1.800 ± 0.06***	0.223 ± 0.10^#
BIL total mg/dL	0.247 ± 0.06	0.580 ± 0.05**	0.300 ± 0.07^#	0.660 ± 0.10**	0.417 ± 0.14^#
BIL direct mg/dL	0.113 ± 0.03	0.297 ± 0.06*	0.153 ± 0.03^#	0.433 ± 0.10***	0.223 ± 0.10^#
ALP U/L	29.85 ± 7.90	220.64 ± 45.39***	47.63 ± 10.37^#	246.25 ± 47.19***	88.57 ± 23.59^#
SGOT U/L	40.66 ± 11.55	174.95 ± 19.80***	50.45 ± 4.37^#	184.74 ± 19.10***	131.78 ± 18.57^#
SGPT U/L	38.73 ± 6.91	138.24 ± 10.96***	49.67 ± 5.74^#	148.43 ± 10.94***	76.24 ± 10.68**
Hb mg/dL	13.35 ± 0.66	10.96 ± 1.86^#	12.21 ± 1.33***	6.88 ± 0.38^#	11.78 ± 0.25^#

Data represent mean ± SD of three replicates (𝑃<0.05). One-way ANOVA followed by Dunnett’s Multiple Comparison Test was used to compare control group from other experimental groups (^#𝑃<0.05, ^∗𝑃<0.01, ^∗∗𝑃<0.001, and ^∗∗∗𝑃<0.0001). INH: isoniazid, L52: Liv52, SP: Syngonium podophyllum, EC: Eichhornia crassipes, CRE: creatinine, BIL: bilirubin, ALP: alkaline phosphatase, SGOT: serum glutamic oxaloacetic transaminase, SGPT: serum glutamate pyruvate transaminase, and Hb: haemoglobin.