Biological Evaluation of ¹³¹I- and CF750-Labeled Dmab(scFv)-Fc Antibodies for Xenograft Imaging of CD25-Positive Tumors

Table 1

Tissue distribution of ¹³¹I-labeled Dmab(scFv)-Fc antibody in mice bearing Hut102 xenograft (𝑛=3).

	1 h	3 h	5 h	9 h	24 h
Tissue
Blood	48.70±0.91	36.95±3.55	22.42±0.38	14.24±0.06	4.35±0.25
Heart	31.15±6.22	20.31±4.21	10.25±1.34	6.10±0.75	1.53±0.14
Liver	39.01±8.19	28.29±4.10	20.72±0.84	16.87±1.44	6.05±1.34
Spleen	52.92±7.16	31.98±1.50	20.17±3.61	15.61±0.76	5.00±2.24
Lung	32.59±4.81	28.09±3.91	13.92±2.91	8.38±1.06	1.91±0.18
Kidney	47.32±5.79	40.12±6.90	29.85±2.39	22.12±1.90	8.48±0.39
Brain	2.47±1.59	3.50±0.77	1.43±0.33	0.74±0.12	0.17±0.06
Muscle	11.37±2.97	10.43±2.33	4.77±1.52	3.20±0.48	0.57±0.09
Tumor	28.77±6.43	28.94±5.81	19.98±5.15	13.43±1.12	3.61±0.37
Ratio
Tumor/brain	8.56±1.98	8.34±1.39	13.9±0.82	18.49±4.32	22.42±7.21
Tumor/muscle	2.61±0.75	2.79±0.38	4.33±0.94	4.27±0.85	6.45±1.16

Tumor and normal tissue uptakes are expressed as percent injected dose per gram (%ID/g ± SD).