Research Article
Increased Release Time of Antibiotics from Bone Allografts through a Novel Biodegradable Coating
Table 1
Technical requirements against a local antibiotic formulation in the 3 main categories of orthopedic use in endoprosthesis surgery.
| | Medical purpose | Probability of infection | Antibiogram | Required length of local antibiotic treatment | Typical local antibiotic formulation | Reference |
| Primary implantation | Prevention of infection arising from contamination at surgery or early postoperation | 0.5–2% | Not available | 1-2 days or until the surgical site is open through drainage | Antibiotic bone cement, off-the-shelf | [27–30] |
| Aseptic revision | Prevention of infection arising from either contamination or a low-grade infection | n/a | Not available, or its reliability is low | 1-2 days or until the surgical site is open through drainage. Longer if low-grade infection is suspected. | Antibiotic bone cement, bone substitutes, freehand use of local antibiotic powder or solution | [27, 31] |
| Septic revision | Eradication of bacterial infection | 100% | Available | Several weeks | Antibiotic bone cement, freehand use of local antibiotic powder or solution. Bone substitutes are contraindicated. | [18, 27, 31, 32] |
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