Increased Release Time of Antibiotics from Bone Allografts through a Novel Biodegradable Coating

Table 4

Calculated antibiotic content of the coated bone compared to the daily doses in clinical practice.

	24 hours from 0.05 g bone	28th day from 0.05 g bone	24 hours from 45 g bone	28th day from 45 g bone	Daily dose/reference (mg/day)
Amoxicillin (mg)	0.26		234		6000 [33]
% of daily dose	0.004		3.9
Ciprofloxacin (mg)	0.674	0.015	606.72	13.03	1500 [34]
% of daily dose	0.045	0.001	40.45	0.87
Vancomycin (mg)	0.485	0.05	436.87	44.68	1000 [35]
% of daily dose	0.049	0.005	43.687	4.468