Review Article
Radiation Oncology In Vitro: Trends to Improve Radiotherapy through Molecular Targets
Table 1
Molecular targets related with intracellular signaling pathways in different tumor cell lines.
| Tumor type | Cell line | Proliferation targets | Migration targets | Angiogenesis targets | DNA targets |
| Breast | MDAMB-231 MCF-7 | SphK1 Akt | PGE2 MMP-2 | | DNA-PKcs |
| Head and neck | SQ20B FaDu A431 UM-SCC1 UM-SCC6 UT-SCC15 | PI3K/mTOR EGFR ADAM-17 nuclear Ca2+ | | HIF-1α | PARP HDAC p53 |
| Glioblastoma | U251 | PI3KmTOR | αvβ3 | | |
| Bladder | UM-UC3 UM-UC5 UM-UC6 KU7 253J-BV 253-JP | mTOR cyclin D1 p27 p21 | | | |
| Lung | A549 H3255 Calu-6 | EGFR E-TKI PI3KAkt | Akt2 TGFβ α2β1 Src COX-2 MMP-9 | VEGFR TGF-β1 | PARP-1 HDAC |
| Colorectal | WiDr DLD-1 RKO KM20 | EGFR PI3KmTOR | Akt2 TGFβ ST6Gal I | HIF-1α | HDAC |
| Prostate | PC-3 DU-145 | PI3KmTOR | | | PARP-1 p53 |
| Cervix | HeLa FIR | PI3K | p65 NF-kB | | DNA-PKcs |
| Liver | HepG2 McA-RH77 KM20 | nuclear Ca2+ PI3KAkt | MMP-2 MMP-9 | VEGF | |
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