Review Article

Radiation Oncology In Vitro: Trends to Improve Radiotherapy through Molecular Targets

Table 1

Molecular targets related with intracellular signaling pathways in different tumor cell lines.

Tumor typeCell lineProliferation targetsMigration targetsAngiogenesis targetsDNA targets

Breast MDAMB-231
MCF-7
SphK1
Akt
PGE2
MMP-2
DNA-PKcs

Head and neckSQ20B
FaDu
A431
UM-SCC1
UM-SCC6
UT-SCC15
PI3K/mTOR
EGFR
ADAM-17
nuclear Ca2+
HIF-1αPARP
HDAC
p53

GlioblastomaU251PI3KmTORαvβ3

BladderUM-UC3
UM-UC5
UM-UC6
KU7
253J-BV
253-JP
mTOR
cyclin D1
p27
p21

LungA549
H3255
Calu-6
EGFR
E-TKI
PI3KAkt
Akt2
TGFβ
α2β1
Src
COX-2
MMP-9
VEGFR
TGF-β1
PARP-1
HDAC

ColorectalWiDr
DLD-1
RKO
KM20
EGFR
PI3KmTOR
Akt2
TGFβ
ST6Gal I
HIF-1αHDAC

ProstatePC-3
DU-145
PI3KmTORPARP-1
p53

CervixHeLa
FIR
PI3Kp65 NF-kBDNA-PKcs

LiverHepG2
McA-RH77
KM20
nuclear Ca2+
PI3KAkt
MMP-2
MMP-9
VEGF