Solubility and Bioavailability Enhancement of Poorly Aqueous Soluble Atorvastatin: In Vitro, Ex Vivo, and In Vivo Studies

Table 3

Solubility studies of atorvastatin (mean ± standard deviation) from physical mixture and solid dispersions in comparison with plain drug.

Product	Solubility (mg/mL)
ATR	0.190 ± 0.04
PM	0.241 ± 0.09
KM	0.746 ± 0.65****
SE	0.843 ± 0.14****

𝑛=3; 𝑃<0.05; ATR: atorvastatin; PM: physical mixture; KM: kneading method; and SE: solvent evaporation method.
****refers to significant difference amongst treatment groups.