Solubility and Bioavailability Enhancement of Poorly Aqueous Soluble Atorvastatin: In Vitro, Ex Vivo, and In Vivo Studies

Table 5

Dissolution efficiency of ATR and various solid dispersions.

Formulation	DE 30 min	DE 120 min
ATR	44.74±4.43	76.86±1.43
PM 1 : 1	50.66±1.52	80±1
PM 1 : 3	52.4±2.13	79±1
PM 1 : 6	63.45±1.95	83.82±2.3
KM 1 : 1	83.43±2.3	97±1.53
KM 1 : 3	74.15±1.53	92.88±1.37
KM 1 : 6	88.47±2.77^∗∗∗∗	97.84±1
SE 1 : 1	90.96±4.28	99±1.59
SE 1 : 3	92.84±2.45	101±0.277
SE 1 : 6	95.47±1.04^∗∗∗∗	101±1

𝑛=3, 𝑃<0.05.
ATR: atorvastatin; PM: physical mixture; KM: kneading method; and SE: solvent evaporation method.
****refers to significant difference amongst treatment groups.