Subchronic Toxicity Study in Rats of Two New Ethyl-Carbamates with Ixodicidal Activity

Figure 3

Histopathological findings from the rats that were subchronically exposed to the carbamate LQM 919. (A) Liver section (10x) of an unexposed rat (control). (B) Liver section (20x) of a rat that was exposed to 50 mg/kg/day of LQM 919 that exhibits highly euchromatic nuclei (hen), hepatocytes with two nuclei (dn), and colestasis (c). (C) Liver section (10x) that exhibits a degenerated area and congestion. (D) Kidney section (10x) of an unexposed rat (control). (E) Kidney section (10x) of a rat that was exposed to 50 mg/kg/day of carbamate that shows hemosiderin deposits (h). (F) Ovary section (20x) of an exposed rat (50 mg/kg/day) showing hemosiderin deposits (h).