Association between Two Common Polymorphisms and Risk of Hepatocellular Carcinoma: Evidence from an Updated Meta-Analysis

Table 1

Characteristics of literatures included in the meta-analysis on hepatocellular carcinoma.

Author	Year	Country	Ethnicity	Source of controls	Genotyping method	Cases/controls	MicroRNA polymorphism	Allele frequency; G/C or C/T	HWE
Xu et al. [36]	2008	China	Asian	Population	PCR-RFLP	479/504	miR-146a G>C	0.36/0.64	0.119
Xu [37]	2010	China	Asian	Population	PCR-RFLP	500/522	miR-146a G>C	0.39/0.61	0.296
						492/495	miR-196a2 C>T	0.46/0.54	0.621
Qi et al. [33]	2010	China	Asian	Population	PCR-LDR	361/391	miR-196a2 C>T	0.49/0.51	0.869
Li et al. [31]	2010	China	Asian	Hospital	PCR-RFLP	310/222	miR-196a2 C>T	0.42/0.58	0.402
Wang [34]	2011	China	Asian	Population	MALDI-TOF	1116/1869	miR-146a G>C	0.39/0.61	0.115
Akkiz et al. [25]	2011	Turkey	Caucasian	Population	PCR-RFLP	222/222	miR-146a G>C	0.80/0.20	0.384
Akkiz et al. [26]	2011	Turkey	Caucasian	Population	PCR-RFLP	185/185	miR-196a2 C>T	0.55/0.45	0.492
Zhang et al. [39]	2011	China	Asian	Population	PIRA-PCR	925/840	miR-146a G>C	0.41/0.59	0.149
						934/837	miR-196a2 C>T	0.47/0.53	0.972
Yu [38]	2012	China	Asian	Population	PCR-RFLP	100/100	miR-146a G>C	0.44/0.56	0.506
Li [32]	2012	China	Asian	Population	AS-PCR	560/560	miR-146a G>C	0.42/0.58	0.196
						560/560	miR-196a2 C>T	0.39/0.61	0.056
Kim et al. [30]	2012	Korea	Asian	Population	PCR-RFLP	159/201	miR-146a G>C	0.38/0.62	0.190
						159/201	miR-196a2 C>T	0.49/0.51	0.356
Xiang et al. [35]	2012	China	Asian	Population	PCR-RFLP	100/100	miR-146a G>C	0.44/0.56	0.506
Zhou et al. [41]	2012	China	Asian	Population	PCR-RFLP	186/483	miR-146a G>C	0.41/0.59	0.056
Huang et al. [29]	2013	China	Asian	Population	MALDI-TOF	110/110	miR-146a G>C	0.32/0.68	0.122
Zhang et al. [40]	2013	China	Asian	Population	MassArray	997/998	miR-146a G>C	0.39/0.61	0.911
						996/995	miR-196a2 C>T	0.42/0.58	0.245
Han et al. [27]	2013	China	Asian	Population	RT-PCR	1017/1009	miR-196a2 C>T	0.46/0.54	0.310
Hao et al. [28]	2013	China	Asian	Population	PCR-RFLP	235/281	miR-146a G>C	0.38/0.62	0.056
						235/281	miR-196a2 C>T	0.52/0.48	0.051

HWE: Hardy-Weinberg equilibrium; PCR: polymerase chain reaction; RFLP: restriction fragment length polymorphism; PIRA: primer introduced restriction analysis; LDR: ligase detection reaction; AS: allele specific; MALDI-TOF: matrix-assisted laser desorption/ionization time-of-flight.