Research Article
Genetic Variants in the Genes of the Stress Hormone Signalling Pathway and Depressive Symptoms during and after Pregnancy
Table 1
Genotype and allele distribution for each single nucleotide polymorphism (SNP). Absolute frequencies and percentages (in brackets) are shown.
| | SNP | Chrom.1 | Position | Alleles2 | MAF3 (%) | Homozygous, common4 | Heterozygous4 | Homozygous rare4 |
| | rs1360780 (FKBP5) | 6 | 35607571 | C/T | 32.0 | 168 (46.5) | 155 (43.2) | 38 (10.5) | | rs9296158 (FKBP5) | 6 | 35567082 | G/A | 32.0 | 166 (46.1) | 156 (43.3) | 37 (10.2) | | rs3800373 (FKBP5) | 6 | 35542476 | T/G | 28.4 | 185 (51.8) | 147 (40.7) | 29 (8.0) | | rs9470080 (FKBP5) | 6 | 35646435 | C/T | 34.7 | 155 (42.9) | 160 (44.6) | 45 (12.5) | | rs41423247 (NR3C1) | 5 | 142778575 | G/C | 34.7 | 156 (43.3) | 158 (43.9) | 46 (12.7) | | rs6195 (NR3C1) | 5 | 142779317 | A/G | 4.7 | 327 (91.6) | 34 (9.4) | 0 (0.0) | | rs10482605 (NR3C1) | 5 | 142783521 | T/C | 18.3 | 242 (67.0) | 99 (27.6) | 16 (4.4) | | rs110402 (CRHR1) | 17 | 43880047 | C/T | 45.3 | 110 (30.6) | 175 (48.6) | 76 (21.1) | | rs7209436 (CRHR1) | 17 | 43870142 | C/T | 44.0 | 115 (32.2) | 174 (48.2) | 72 (19.9) |
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Chromosome; 2major/minor allele, based on the forward strand and minor allele frequency; 3minor allele frequency; 4frequency, percentage in brackets.
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