Research Article

Aaptamines from the Marine Sponge Aaptos sp. Display Anticancer Activities in Human Cancer Cell Lines and Modulate AP-1-, NF-κB-, and p53-Dependent Transcriptional Activity in Mouse JB6 Cl41 Cells

Table 1

Anticancer activity of aaptamines 13 against several human cancer cell lines. Cells were treated with the indicated concentrations of the substances for 24 h. All experiments were performed in triplicate.

Cancer typeCell lineCompound (IC50, M)
123

Monocytic leukemiaTHP-1
Cervical carcinomaHeLa
Colon cancerSNU-C4
MelanomaSK-MEL-28
Breast cancerMDA-MB-231