Toxicity Profile of a Nutraceutical Formulation Derived from Green Mussel Perna viridis

Table 1

Body weight and food and water consumption during subchronic (90 days) toxicity studies after the administration of green mussel formulation.

Days	Male				Female
	Control^a	2.0 g/kg^b	1.0 g/kg^b	0.50 g/kg^b	Control^a	2.0 g/kg^b	1.0 g/kg^b	0.50 g/kg^b
Body weight (g)
0	230.8±1.4	254.9±2.5	263.6±14.2	284.4±0.5	185.8±1.5	218.5±15.6	195.8±1.4	190.9±5.2
14	239.6±4.5	261.8±1.5	270.4±2.2	290.1±1.4	192.4±2.4	224.4±12.5	202.1±2.6	196.8±6.2
42	252.4±6.6	273.9±6.5	281±18.6	300±1.5	204±2.6	232.6±11.6	212.1±3.2	206.9±2.6
70	263.8±8.5^∗	283.6±1.5^∗	290.2±19.5	308.4±1.6^∗	214.2±2.6^∗	240.9±11.4^∗	220.7±1.2^∗	216.2±2.4^∗
91	271.58±14.2^∗	290.8±1.6^∗	296.7±2.1^∗	314.5±1.2^∗	221.1±0.9^∗	246.6±0.5^∗	226.8±0.5^∗	222.5±2.9^∗
Food consumption (g)
0	72.4±5.6	74.4±2.5	70.6±6.5	68.7±1.2	59.5±0.6	55.4±1.6	58±2.3	62.7±0.9
14	66.4±6.5	73.3±3.6	62.6±6.3	61.3±1.5	62.5±1.2	49.3±2.6	54.6±2.6	57.7±1.2
42	67.3±6.9	71.6±3.9	61.4±4.2	60.6±2.5	47.6±1.1	50.6±2.7	48.3±1.5	50±1.3
70	66.6±7.9	72.7±3.8	62.3±3.2	62.5±2.1	47.9±1.5	51.3±2.4	49±2.6	49.7±1.4
91	68.3±8.5	74.7±3.6	63.2±2.6	65.5±2	48.7±1.3	50.8±2.1	49.7±2.8	50±1.5
Water consumption (mL)
0	100±4	90±2	100±2	110±3	100±2	80±2	110±4	90±2
14	90±3	70±5	110±3	100±1	80±4	80±1	70±5	90±2
42	90±2	110±3	90±1	100±2	100±3	80±4	90±1	90±3
70	110±3	110±1	100±5	100±3	100±2	100±1	90±2	110±3
91	100±4	100±2	110±1	100±4	100±1	110±2	100±2	100±3

∗Data presented as mean ± standard deviation (𝑛=5). Significantly different from control: 𝑃<0.05.
^aControl group received 1 mL distilled water.
^bSample group received three doses of green mussel formulation (2.0, 1.0, and 0.5 g/kg rat).