Toxicity Profile of a Nutraceutical Formulation Derived from Green Mussel Perna viridis

Table 4

Serum biochemical analysis data of male and female rats administered the green mussel formulation after subchronic (90 days) toxicity studies.

		Na^+	K^+	Cl^+	HCO3^+	Cholesterol	Triglycerides	HDL	LDL	VLDL
		(m·mol/L)	(m·mol/L)	(m·mol/L)	(m·mol/L)	(mg/dL)	(mg/dL)	(mg/dL)	(mg/dL)	(mg/dL)
Male	Control^a	147.80±0.66	5.50±0.35	105.22±0.47	25.80±0.84	77.40±0.19	137.50±1.01	32.80±0.42	18.60±0.36	26.00±0.89
	2.0 g/kg^b	145.72±2.96	6.05±0.96	104.88±1.19	27.20±1.09	74.20±0.72	138.80±1.8	34.60±0.14	11.80±0.21	27.80±0.95
	1.0 g/kg^b	144.84±0.34	6.24±0.83	104.48±0.80	26.40±0.14	76.20±0.73	152.80±31.24	33.20±0.30	13.75±0.30	30.60±0.06
	0.50 g/kg^b	146.06±2.22	5.15±0.22	104.48±0.44	27.60±0.89	75.20±3.70	126.00±0.22	34.80±0.84	15.20±2.68	25.20±0.79
Female	Control^a	139.98±0.68	4.88±0.10	101.32±1.78	25.60±1.14	75.60±0.44	114.20±01.94	32.20±0.30	20.60±6.87	22.80±0.30
	2.0 g/kg^b	136.94±0.73	5.03±0.57	104.38±0.79	27.40±0.52	63.40±3.36	123.40±0.21	31.00±0.71	7.80±0.49	24.60±0.89
	1.0 g/kg^b	138.18±0.66	5.58±0.61	103.54±0.95	26.60±0.89	75.20±0.68	140.60±0.35	32.80±0.08	16.40±0.28	26.00±0.64
	0.50 g/kg^b	141.14±0.59	5.85±0.88	104.84±0.83	27.20±0.84	72.80±0.03	145.60±0.70	29.20±1.64	14.40±0.91	29.20±0.15

Data presented as mean ± standard deviation (𝑛=5).
^aControl group received 1 mL distilled water.
^bSample group received three doses of green mussel formulation (2.0, 1.0, and 0.5 g/kg rat).
HDL: high-density lipoprotein; LDL: low-density lipoprotein; VLDL: very low-density lipoprotein.