Computational Study to Determine When to Initiate and Alternate Therapy in HIV Infection

<table>SVF and SWATCH treatment strategies. CD4+ T cells and viral load are displayed for different initiation times (<svg height="14.4125" id="M77" style="vertical-align:-3.2316pt" version="1.1" viewbox="0 0 9.7875004 14.4125" width="9.7875004" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
<g transform="matrix(.017,-0,0,-.017,.062,10.125)"><path d="M324 430l-26 -36l-112 -4l-55 -265q-13 -66 7 -66q13 0 44.5 20t50.5 40l17 -24q-38 -40 -85.5 -73.5t-87.5 -33.5q-50 0 -21 138l55 262h-80l-2 8l25 34h66l25 99l78 63l10 -9l-37 -153h128z" id="x1D461"></path></g>
<g transform="matrix(.012,-0,0,-.012,5.862,14.2)"><path d="M244 607q0 -25 -15.5 -43t-37.5 -18q-19 0 -32 13t-13 35q0 21 15 41t39 20q20 0 32 -14t12 -34zM222 91q-29 -33 -79 -68t-75 -35q-13 0 -19 7.5t-6 31t10 65.5l62 253q5 26 -1 26q-21 0 -72 -43l-13 24q43 40 91 68t71 28q30 0 10 -78l-71 -274q-8 -30 3 -30
q16 0 76 48z" id="x1D456"></path></g>
</svg>). The top two panels show simulation results for the SVF strategy and the bottom panels show the results for the SWATCH strategy. Deterministic simulations are based on nominal parameter values from Table <a href="../tab2/">2</a>.</table>

BioMed Research International

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Figure 5

Figure 5: Computational Study to Determine When to Initiate and Alternate Therapy in HIV Infection 