Computational Study to Determine When to Initiate and Alternate Therapy in HIV Infection

Table 1

Panel recommendations for therapy initiation.

		Urgency of initiation
CD4+ T cell count	<350 cells/mm^3	Strong I
	350–500 cells/mm^3	Strong II
	>500 cells/mm^3	Moderate III
Transmission risk	Perinatal	Strong I
	Heterosexual	Strong I
	Other	Strong III

The urgency is rated by validity: I: data from randomized trials, II: data from well-designed nonrandomized trials or observational cohort studies with long-term clinical outcomes, III: expert opinion [3].