Precursor Lesions for Sporadic Pancreatic Cancer: PanIN, IPMN, and MCN

Table 1

Subtype classification of IPMN by immunohistochemical analysis and arising invasive carcinoma [48–50].

IPMN (subtype)	Expression profile	Invasive carcinoma
Intestinal; (MD-IPMN)	MUC5AC ^+, MUC2 ^+, CDX-2 ^+; (MUC1^−, MUC6^−)	Colloidal; carcinoma
Pancreatobiliary; (MD-IPMN)	MUC5AC ^+, MUC1 ^+; (MUC2^−, MUC6^+/−)	Tubular (ductal); carcinoma
Gastric; (BD-IPMN)	MUC5AC ^+, (MUC6 ^+); (MUC1^−, MUC2^−)	Tubular (ductal); carcinoma
Oncocytic; (MD-IPMN)	MUC5AC ^+, MUC6 ^+; (MUC2^+/−) (MUC1^+/−)	Oncocytic; carcinoma