Research Article

Peripheral Injection of SB203580 Inhibits the Inflammatory-Dependent Synthesis of Proinflammatory Cytokines in the Hypothalamus

Figure 4

Effect of lipopolysaccharide (LPS) (400 ng/kg; i.v./7 days) and SB203580 (500 μg/kg) injections on the gene expression of TNFα (a), TNFR1 (b), and TNFR2 (c) in the hypothalamus on day 7 of the experiment. a, b, c— (indicate values that differ significantly from the control, SB203580 control, and LPS treated groups, resp., according to the Mann-Whitney test). Data are presented as a mean value ± S.E.M.
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(a)
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(b)
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(c)