About this Journal Submit a Manuscript Table of Contents
BioMed Research International
Volume 2014 (2014), Article ID 480921, 7 pages
http://dx.doi.org/10.1155/2014/480921
Research Article

Antisecretory Effect of Hydrogen Sulfide on Gastric Acid Secretion and the Involvement of Nitric Oxide

1Research Institute for Infectious Diseases of Digestive System, Physiology Research Center (PRC) and Department of Physiology, The School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz 61357 15794, Iran
2Department of Physiology, The School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
3Research Institute for Infectious Diseases of Digestive System, The School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz 61357 15794, Iran
4Research Institute for Infectious Diseases of Digestive System and Department of Virology, The School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz 61357 15794, Iran

Received 20 April 2013; Revised 24 December 2013; Accepted 8 January 2014; Published 24 February 2014

Academic Editor: David Bernardo Ordiz

Copyright © 2014 Seyyed Ali Mard et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. P. K. Moore, M. Bhatia, and S. Moochhala, “Hydrogen sulfide: from the smell of the past to the mediator of the future?” Trends in Pharmacological Sciences, vol. 24, no. 12, pp. 609–611, 2003. View at Publisher · View at Google Scholar · View at Scopus
  2. R. Wang, “Two's company, three's a crowd: can H2S be the third endogenous gaseous transmitter?” FASEB Journal, vol. 16, no. 13, pp. 1792–1798, 2002. View at Publisher · View at Google Scholar · View at Scopus
  3. H. Kimura, “Hydrogen sulfide: its production, release and functions,” Amino Acids, vol. 41, no. 1, pp. 113–121, 2011. View at Publisher · View at Google Scholar · View at Scopus
  4. W. Zhao, J. Zhang, Y. Lu, and R. Wang, “The vasorelaxant effect of H2S as a novel endogenous gaseous KATP channel opener,” The EMBO Journal, vol. 20, no. 21, pp. 6008–6016, 2001. View at Publisher · View at Google Scholar · View at Scopus
  5. H. Kimura, “Hydrogen sulfide as a neuromodulator,” Molecular Neurobiology, vol. 26, no. 1, pp. 13–19, 2002. View at Scopus
  6. R. Hosoki, N. Matsuki, and H. Kimura, “The possible role of hydrogen sulfide as an endogenous smooth muscle relaxant in synergy with nitric oxide,” Biochemical and Biophysical Research Communications, vol. 237, no. 3, pp. 527–531, 1997. View at Publisher · View at Google Scholar · View at Scopus
  7. S. Fiorucci, E. Antonelli, E. Distrutti et al., “Inhibition of hydrogen sulfide generation contributes to gastric injury caused by anti-inflammatory nonsteroidal drugs,” Gastroenterology, vol. 129, no. 4, pp. 1210–1224, 2005. View at Publisher · View at Google Scholar · View at Scopus
  8. J. L. Wallace, M. Dicay, W. McKnight, and G. R. Martin, “Hydrogen sulfide enhances ulcer healing in rats,” FASEB Journal, vol. 21, no. 14, pp. 4070–4076, 2007. View at Publisher · View at Google Scholar · View at Scopus
  9. S. A. Mard, N. Neisi, G. Solgi, M. Hassanpour, M. Darbor, and M. Maleki, “Gastroprotective effect of NAHS against mucosal lesions induced by ischemia-reperfusion injury in rat,” Digestive Diseases and Sciences, vol. 57, no. 6, pp. 1496–1503, 2012. View at Publisher · View at Google Scholar
  10. W. Zhao and R. Wang, “H2S-induced vasorelaxation and underlying cellular and molecular mechanisms,” The American Journal of Physiology: Heart and Circulatory Physiology, vol. 283, no. 2, pp. H474–H480, 2002. View at Scopus
  11. F. Ise, H. Takasuka, S. Hayashi et al., “Stimulation of duodenal HCO3 secretion by hydrogen sulphide in rats: Relation to prostaglandins, nitric oxide and sensory neurones,” Acta Physiologica, vol. 201, no. 1, pp. 117–126, 2011. View at Publisher · View at Google Scholar · View at Scopus
  12. H. Kim and K. H. Kim, “Effects of a nitric oxide donor and nitric oxide synthase inhibitors on acid secretion of isolated rabbit gastric glands,” Pharmacology, vol. 53, no. 6, pp. 331–339, 1996. View at Scopus
  13. A. Berg, S. Redeen, A.-C. Ericson, and S. E. Sjöstrand, “Nitric oxide-an endogenous inhibitor of gastric acid secretion in isolated human gastric glands,” BMC Gastroenterology, vol. 4, article 16, 2004. View at Publisher · View at Google Scholar · View at Scopus
  14. S. Kato, M. Kitamura, R. P. Korolkiewicz, and K. Takeuchi, “Role of nitric oxide in regulation of gastric acid secretion in rats: effects of NO donors and NO synthase inhibitor,” British Journal of Pharmacology, vol. 123, no. 5, pp. 839–846, 1998. View at Publisher · View at Google Scholar · View at Scopus
  15. S. A. Mard, M. Maleki, M. K. Gharib Naseri, and A. H. Saberi, “Effects of endogenous production and exogenous administration of H2S on gastric acid secretion in rats,” The Journal of Physiology and Pharmacology, vol. 15, no. 4, pp. 499–506, 2011.
  16. K. J. Livak and T. D. Schmittgen, “Analysis of relative gene expression data using real-time quantitative PCR and the 2-ΔΔCT method,” Methods, vol. 25, no. 4, pp. 402–408, 2001. View at Publisher · View at Google Scholar · View at Scopus
  17. L. C. Green, D. A. Wagner, and J. Glogowski, “Analysis of nitrate, nitrite, and 15N nitrate in biological fluids,” Analytical Biochemistry, vol. 126, no. 1, pp. 131–138, 1982. View at Scopus
  18. A. Berg, S. Kechagias, S. E. Sjöstrand, and A.-C. Ericson, “Morphological support for paracrine inhibition of gastric acid secretion by nitric oxide in humans,” Scandinavian Journal of Gastroenterology, vol. 36, no. 10, pp. 1016–1021, 2001. View at Publisher · View at Google Scholar · View at Scopus
  19. N. Arebi, Z. V. Healey, P. W. Bliss et al., “Nitric oxide regulates the release of somatostatin from cultured gastric rabbit primary D-cells,” Gastroenterology, vol. 123, no. 2, pp. 566–576, 2002. View at Publisher · View at Google Scholar · View at Scopus
  20. L.-F. Hu, T.-T. Pan, K. L. Neo, Q. C. Yong, and J.-S. Bian, “Cyclooxygenase-2 mediates the delayed cardioprotection induced by hydrogen sulfide preconditioning in isolated rat cardiomyocytes,” Pflugers Archiv European Journal of Physiology, vol. 455, no. 6, pp. 971–978, 2008. View at Publisher · View at Google Scholar · View at Scopus
  21. J. L. Wallace, L. Vong, W. McKnight, M. Dicay, and G. R. Martin, “Endogenous and exogenous hydrogen sulfide promotes resolution of colitis in rats,” Gastroenterology, vol. 137, no. 2, pp. 569.e1–578.e1, 2009. View at Publisher · View at Google Scholar · View at Scopus
  22. J. V. R. Medeiros, V. H. Bezerra, A. S. Gomes et al., “Hydrogen sulfide prevents ethanol-induced gastric damage in mice: role of ATP-sensitive potassium channels and capsaicin-sensitive primary afferent neurons,” Journal of Pharmacology and Experimental Therapeutics, vol. 330, no. 3, pp. 764–770, 2009. View at Publisher · View at Google Scholar · View at Scopus
  23. E. Aihara, S. Kagawa, M. Hayashi, and K. Takeuchi, “Ace inhibitor and AT1 antagonist stimulate duodenal HCO3 secretion mediated by a common pathway—involvement of PG, NO and bradykinin,” Journal of Physiology and Pharmacology, vol. 56, no. 3, pp. 391–406, 2005. View at Scopus
  24. S. Kagawa, M. Aoi, Y. Kubo, T. Kotani, and K. Takeuchi, “Stimulation by capsaicin of duodenal HCO3 secretion via afferent neurons and vanilloid receptors in rats: comparison with acid-induced HCO3 response,” Digestive Diseases and Sciences, vol. 48, no. 9, pp. 1850–1856, 2003. View at Publisher · View at Google Scholar · View at Scopus
  25. R. Bulut, Y. Ünlüçerçi, S. Bekpinar, and L. Kuntsal, “Nitric oxide-mediated regulation of gastric H+, K+-ATPase and alcohol dehydrogenase following ethanol-induced injury in rats,” Digestive Diseases and Sciences, vol. 44, no. 7, pp. 1417–1422, 1999. View at Publisher · View at Google Scholar · View at Scopus
  26. L. Li, G. Rossoni, A. Sparatore, L. C. Lee, P. Del Soldato, and P. K. Moore, “Anti-inflammatory and gastrointestinal effects of a novel diclofenac derivative,” Free Radical Biology and Medicine, vol. 42, no. 5, pp. 706–719, 2007. View at Publisher · View at Google Scholar · View at Scopus
  27. C. Szabó and A. Papapetropoulos, “Hydrogen sulphide and angiogenesis: mechanisms and applications,” British Journal of Pharmacology, vol. 164, no. 3, pp. 853–865, 2011. View at Publisher · View at Google Scholar · View at Scopus
  28. S. Fiorucci, E. Distrutti, G. Cirino, and J. L. Wallace, “The emerging roles of hydrogen sulfide in the gastrointestinal tract and liver,” Gastroenterology, vol. 131, no. 1, pp. 259–271, 2006. View at Publisher · View at Google Scholar · View at Scopus
  29. P. Zhao, X. Huang, Z.-Y. Wang et al., “Dual effect of exogenous hydrogen sulfide on the spontaneous contraction of gastric smooth muscle in guinea-pig,” European Journal of Pharmacology, vol. 616, no. 1–3, pp. 223–228, 2009. View at Publisher · View at Google Scholar · View at Scopus
  30. Y.-F. Han, X. Huang, X. Guo et al., “Evidence that endogenous hydrogen sulfide exerts an excitatory effect on gastric motility in mice,” European Journal of Pharmacology, vol. 673, no. 1–3, pp. 85–95, 2011. View at Publisher · View at Google Scholar · View at Scopus