Research Article
Mutation Analysis of JAK2V617F, FLT3-ITD, NPM1, and DNMT3A in Chinese Patients with Myeloproliferative Neoplasms
Table 1
Basic characteristic of JAK2V617F-positive and negative MPN patients.
| | All patients | JAK2V617F mutation | value | | Negative | Positive |
| | Number (%) | | | | | | All patients | 120 | 48 (40%) | 72 (60%) | | | PV patients | 25 | 6 (24%) | 19 (76%) | | | ET patients | 55 | 22 (40%) | 33 (60%) | | | MF patients | 24 | 15 (62.5%) | 9 (37.5%) | | | MPN-u patients | 15 | 5 (33.3%) | 10 (66.7%) | | | CNL patients | 1 | 0 (0%) | 1 (100%) | | | Age (years), | | | | | | All patient | 55 ± 16 | 48 ± 16 | 60 ± 11 | 0.000 | | PV patients | 53 ± 23 | 40 ± 15 | 63 ± 8 | 0.011 | | ET patients | 53 ± 3 | 47 ± 17 | 57 ± 12 | 0.016 | | MF patients | 58 ± 12 | 56 ± 14 | 62 ± 4 | 0.184 | | MPN-u patients | 53 ± 0 | 43 ± 20 | 58 ± 12 | 0.183 | | CNL patients | 68 | — | 68 | | | Gender (Male/Female) | | | | | | All patients | 56/64 | 21/27 | 35/37 | 0.709 | | PV patients | 15/10 | 5/1 | 10/9 | 0.345 | | ET patients | 20/35 | 8/18 | 12/17 | 0.575 | | MF patients | 15/9 | 6/5 | 9/4 | 0.675 | | MPN-u patients | 6/9 | 2/3 | 4/6 | 1.000 | | CNL patients | 0/1 | — | 0/1 | |
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value refers to the comparison of JAK2V617F-positive versus -negative subjects.
MPN: myeloproliferative neoplasms; PV: polycythemia vera; ET: essential thrombocythemia; MF: myelofibrosis; MPN-u: MPN-unclassifiable; CNL: chronic neutrophilic leukemia.
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