Research Article
Mutation Analysis of JAK2V617F, FLT3-ITD, NPM1, and DNMT3A in Chinese Patients with Myeloproliferative Neoplasms
Table 3
JAK2V617F mutation and peripheral hemogram.
| | JAK2V617F | Number | WBC (109/L) | RBC (1012/L) | HB (g/L) | PLT (109/L) |
| | PV | 21 | | | | | | Mutation | 16 | 11.2 ± 4.5 | 6.8 ± 1.1 | 185.6 ± 32.4 | 362.2 ± 222.3 | | Wild type | 5 | 9 ± 5.7 | 6.2 ± 1.7 | 190.2 ± 37.4 | 185.7 ± 71.2 | | value | | 0.383 | 0.543 | 0.813 | 0.015 | | ET | 35 | | | | | | Mutation | 20 | 19.4 ± 15.5 | 4.4 ± 0.8 | 133.2 ± 24.7 | 1046.8 ± 608.3 | | Wild type | 15 | 9.3 ± 5 | 3.8 ± 0.8 | 110.1 ± 21.9
| 871.8 ± 296.9 | | value | | 0.012 | 0.052 | 0.013 | 0.272 | | MF | 22 | | | | | | Mutation | 8 | 18.7 ± 12.8 | 3.4 ± 1.3 | 83.5 ± 21.4 | 188 ± 51.2
| | Wild type | 14 | 8.1 ± 9.2 | 2.6 ± 1.0 | 74 ± 26.5 | 99.9 ± 89.5 | | value | | 0.035 | 0.179 | 0.372 | 0.135 | | MPN-u | 6 | | | | | | Mutation | 4 | 23.8 ± 6.0 | 5.7 ± 2 | 141 ± 43.8 | 549.8 ± 221.5 | | Wild type | 2 | 27.4 ± 17.8 | 3.5 ± 1.5 | 95.4 ± 43.3 | 1125.5 ± 839.3 | | value | | 0.821 | 0.251 | 0.293 | 0.507 | | CNL | 1 | | | | | | Mutation | 1 | 26.77 ± 0 | 4.22 ± 0 | 138.5 ± 0 | 233 ± 0 |
| | Total | 85 | | | | | | Mutation | 49 | 17.3 ± 12.2 | 5.2 ± 1.7 | 143 ± 45.1 | 639.8 ± 554.4 | | Wild type | 36 | 9.8 ± 8.5 | 3.7 ± 1.6 | 106.2 ± 47.2 | 490.4 ± 467.6 | | value | | 0.002 | 0.000 | 0.001 | 0.197 |
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value refers to the comparison of JAK2V617F-positive versus -negative subjects.
MPN: myeloproliferative neoplasms; PV: polycythemia vera; ET: essential thrombocythemia; MF: myelofibrosis; MPN-u: MPN-unclassifiable; CNL: chronic neutrophilic leukemia; WBC: white blood cell; RBC: red blood cell; HB: hemoglobin; PLT: platelet.
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