Freeze-Drying of Plant Tissue Containing HBV Surface Antigen for the Oral Vaccine against Hepatitis B

<div>Preservation of S-HBsAg VLP-formed (a) and total (b) during freeze-drying replication tests. Each batch was run under the profile of 20°C/22 h–22°C/2 h and with 500 mM sucrose as the excipient. The Vth and IXth batches were loaded with five separate samples. Letter indexes mark statistically homogenous groups, separately for the total and VLP-assembled S-HBsAg.</div>

BioMed Research International

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Figure 5

Figure 5: Freeze-Drying of Plant Tissue Containing HBV Surface Antigen for the Oral Vaccine against Hepatitis B 