Freeze-Drying of Plant Tissue Containing HBV Surface Antigen for the Oral Vaccine against Hepatitis B

Figure 6

Anti-HBs antibody response in mouse serum after oral boosting with S-HBsAg in powdered lyophilised tissue. Material for immunisation was freeze-dried under the 20°C/22 h–22°C/2 h profile with 500 mM sucrose as protective excipient. Symbols: ○ individual mouse response, – group mean value. Letter indexes mark statistically homogenous groups.