[Retracted] MicroRNAs in Hepatocellular Carcinoma: Carcinogenesis, Progression, and Therapeutic Target

Table 2

Upregulated oncogenic miRNAs in HCC.

miRNA	Target genes	Characteristics	References
MiR-15a	Bcl-2, cyclin D1, AKT3	Proliferation, apoptosis	[65]
MiR-16-1	Bcl-2, cyclin D1, AKT3	Proliferation, apoptosis	[65]
MiR-17	c-Myc, E2F	Angiogenesis	[66, 67]
MiR-18	c-Myc, E2F	Angiogenesis	[66, 67]
MiR-19	c-Myc, E2F	Angiogenesis	[66, 67]
MiR-20a	c-Myc, E2F	Angiogenesis	[66, 67]
MiR-21	PTEN	metastasis	[68]
MiR-25	Bim	Apoptosis	[69]
MiR-92-1	c-Myc, E2F	Angiogenesis	[66, 67]
MiR-93	Bim	Apoptosis	[69]
MiR-106b	Bim	Apoptosis	[69]
MiR-148a	PTEN	Metastasis	[70]
MiR-155	RhoA, TLR	Metastasis	[56, 71]
MiR-216a	PTEN	Metastasis	[72]
MiR-221	Bmf; CDKN1B/p27/Kip1; CDKN1C/p57/Kip2, PTEN	Apoptosis; proliferation, angiogenesis	[73–77]
MiR-222	AKT, PTEN	Metastasis, angiogenesis	[51, 74, 78]
MiR-224	Bcl-2, Bcl-w	Apoptosis	[79]
MiR-519d	PTEN	Metastasis	[80]