Review Article
Prognostic Significance of Sentinel Lymph Node Mapping in Merkel Cell Carcinoma: Systematic Review and Meta-Analysis of Prognostic Studies
Table 2
Detailed survival analysis of the cases included in the individual patient analysis (
).
| Factor | Number of patients | HR for OS 95% CI | value | HR for DFS 95% CI | value |
| Age | Mean 68.58 | 1.039 0.98–1.09 | 0.13 | 1.003 0.97–1.03 | 0.83 | Tumor size | Mean 1.85 | 0.59 0.23–1.5 | 0.27 | 1.017 0.65–1.53 | 0.93 | Gender | | | 0.212 | | 0.55 | Male | 78 | 1.86 0.69–5.02 | | 1.23 0.62–2.44 | | Female | 83 | Referent | | Referent | | Regional nodal treatment | | | | | | None | 100 | 0.17 0.04–0.72 | 0.16 | 0.28 0.1–0.78 | 0.015 | Nodal dissection | 23 | 0.78 0.18–3.31 | 0.74 | 0.68 0.22–2.14 | 0.51 | Radiotherapy | 37 | 0.66 0.11–3.99 | 0.65 | 0.37 0.1–1.29 | 0.12 | Both | 12 | Referent | Referent | Referent | Referent | Tumor location | | | | | | Limbs | 95 | 0.95 0.33–2.71 | 0.93 | 0.73 0.37–1.46 | 0.38 | Trunk | 8 | 2.08 0.24–17.52 | 0.46 | 1.95 0.56–6.77 | 0.29 | Head and neck | 69 | Referent | Referent | Referent | Referent | SLN status | | | 0.002 | | 0.015 | Positive | 65 | 6.13 1.97–19.07 | | 2.25 1.16–4.33 | | Negative | 107 | Referent | | Referent | |
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