XRCC1 Arg399Gln and Arg194Trp Polymorphisms and Risk of Systemic Lupus Erythematosus in an Iranian Population: A Pilot Study

Table 3

Genotypes and alleles frequency of XRCC1 polymorphisms in SLE patients and controls.

Polymorphism	SLE patients, 𝑛=163	Controls, 𝑛=180	P value	OR (95% CI)
Arg399Gln
Genotypes, n (%)
Arg/Arg	64 (39.3)	41 (22.8)		1
Arg/Gln	75 (46)	110 (61.2)	0.001	0.44 (0.27–0.71)
Gln/Gln	24 (14.7)	29 (16)	0.063	0.73 (0.5–1.02)
Alleles, n (%)
Arg	203 (62.2)	192 (53.3)		1
Gln	123 (37.7)	168 (46.7)	0.02	0.7 (0.5–0.94)
Arg194Trp
Genotypes, n (%)
Arg/Arg	106 (65)	112 (62.2)		1
Arg/Trp	52 (32)	65 (36.1)	0.47	0.85 (0.54–1.3)
Trp/Trp	5 (3)	3 (1.7)	0.45	1.3 (0.64–2.75)
Alleles, n (%)
Arg	264 (81)	289 (80.3)		1
Trp	62 (19)	71 (19.7)	0.8	0.96 (0.65–1.4)