Phytochemical Evaluation, Antimicrobial Activity, and Determination of Bioactive Components from Leaves of Aegle marmelos

Table 6

Activity of the phytocomponents identified from methanolic leaf extract of Aegle marmelos.

S. no.	R.T	Compound name	Molecular formula	MW	Peak area %	Compound nature	**Activity
1	7.178	4H-Pyran-4-one, 2,3-dihydro-3,5-dihydroxy-6-methyl-	C6H8O4	144	1.11	Flavonoid fraction	Antimicrobial, anti-inflammatory, antiproliferative
2	6.555	1-Butanol, 3-methyl-, acetate	C7H14O2	130	5.32	Alcoholic compound	Antimicrobial
3	12.09	2,3 Dioxabicyclo[2.2.2]oct-5-ene, 1-methyl-4-(1-methylethyl)-(Limonene dioxide 1)	C10H16O2	168	0.53	Terpene	antimicrobial; activity
4	13.385	Bicyclo[3.1.1]heptane-2,3-diol, 2,6,6-trimethyl; (2,3-Pinanediol)	C10H18O2	170	0.97	Terpene	antimicrobial; activity
4	13.762	2-Cyclohexen-1-one, 4-hydroxy-3-methyl-6-(1-methylethyl)-	C10H16O2	168	0.63		antibacterial
5	15.203	1-Dodecanol	C12H26O	186	4.83	long-chain fatty alcohol	antibacterial
6	16.143	Phenol, 2,6-bis(1,1-dimethylethyl)-4-methyl; (BHT)	C15H24O	220	0.87		Antimicrobial, antioxidant; activity
7	16.457	Benzoic acid, 4-ethoxy-, ethyl ester	C11H14O3	194	0.33	Aromatic; acid ester	Antimicrobial Preservative
8	18.101	2-Propanol, 1,1′-[(1-methyl-1,2-ethanediyl)bis(oxy)]bis-(Tripropylene glycol)	C9H20O4	192	0.87		Antimicrobial; activity
9	20.189	1-Tetradecanol, acrylate	C17H32O2	268	1.46	Fatty acid esters	Anti-inflammatory,; antimicrobial
10	20.523	1,3,4,5-Tetrahydroxy-cyclohexanecarboxylic acid; (Quinic acid)	C7H12O6	192	0.39	Aromatic acid	antimicrobial; activity, anti-inflammatory
11	21.839	Tetradecanoic acid; (Myristic acid)	C14H28O2	228	2.00	Fatty acid	Antifungal, Antioxidant, cancer preventive,; nematicide, hypercholesterolemic,; Lubricant
12	22.070	2(4H)-Benzofuranone 5,6,7,7a-tetrahydro-6-hydroxy-4,4,7a-trimethyl	C11H16O3	196	0.26	Triterpene	antimicrobial
13	22.262	1-Heptadecanol; (1-Eicosanol)	C17H36O	256	0.33	Aliphatic alcohol	Antimalarial, antifungal, Antioxidant
14	22.409	1,3-Cyclohexadiene, 2-methyl-5-(1-methylethyl)-(1-Phellandrene)	C10H16	136	0.23	Monoterpene	Antibacterial
15	22.736	1,6-Octadiene, 7-methyl-3-methylene; (beta.-myrcene)	C10H16	136	0.13	Monoterpene	Antibacterial
16	23.404	2-Propenoic acid, 3-(4-hydroxy-3-methoxyphenyl)-, methyl ester; (Cinnamic acid, 4-hydroxy-3-methoxy-, methyl ester )	C11H12O4	208	0.66	Aromatic methyl esters	Antimicrobial,; antioxidant, antiviral
17	23.819	Pentadecanoic acid	C15H30O2	242	0.08	Fatty acid	Antibacterial
18	24.897	3,7,11,15-Tetramethyl-2-hexadecen-1-ol; (Phytol)	C20H40O	296	0.32	Diterpene	Antimicrobial, anticancer, anti-inflammatory, anti-diuretic,
19	24.986	hexadecanoic acid, methyl ester; (Palmitic acid methyl ester)	C17H34O2	270	0.72	Fatty acid methyl ester	Antioxidant, hypocholesterolemic nematicide, pesticide, antiandrogenic flavor, hemolytic, 5-Alpha reductase inhibitor
20	24.951	Pentadecanoic acid	C15H30O2	242	7.99	Saturated fatty acid	Antimicrobial
21	27.266	9-Octadecenoic acid	C18H34O2	282	0.31	Unsaturated fatty acid	antibacterial
22	27.664	Heptadecanoic acid	C17H34O2	270	0.39	Saturated fatty acid	Antimicrobial
23	28.298	9,12,15-Octadecatrienoic acid, methyl ester; (Linolenic acid, methyl ester)	C19H32O2	292	1.07	Fatty acid methyl ester	Antibacterial and anticandidal; Antiinflammatory, hypocholesterolemic, cancer preventive,; hepatoprotective, nematicide, insectifuge antihistaminic,; antiarthritic, anticoronary, antieczemic antiacne, 5-Alpha; reductase inhibitor Antiandrogenic
24	28.554	2-Hexadecen-1-ol, 3,7,11,15-tetramethyl; (Phytol isomer)	C20H40O	296	6.37	Diterpene	Antimicrobial; Anti-inflammatory Anticancer Diuretic
25	29.227	Cis-9-Hexadecenal	C16H30O	238	11.40	Aldehyde	Antimicrobial
26	29.573	Octadecanoic acid; (Stearic acid)	C18H36O2	284	4.06	Fatty acid	Antimicrobial
27	41.240	Benzene, 1,2-dimethoxy-4-[[(4 methylphenyl)sulfonyl]methyl	C16H18O4S	306	10.76	Aromatic sulfur compound	Antimicrobial
28	44.155	Cholest-5-en-3-ol (3.beta.)-	C27H46O	386	0.24	Steroidal	Antibacterial
29	45.238	Ergost-5-en-3-ol, (3.beta.)-	C27H46O	386	0.50	Steroidal	Antimicrobial,; anti-inflammatory; effects
30	45.509	Stigmasta-5,22-dien-3-ol	C29H48O	412	0.63	Steroidal	Antioxidant,; antibacterial activity, antiinflammatory, antiarthritic antiasthma, diuretic
31	46.038	Stigmast-5-en-3-ol, (3.beta.)-	C29H50O	414	3.08	Steroidal	Antimicrobial antioxidant antiinflammatory antiarthritic antiasthma diuretic
32	47.033	Vitamin E	C29H50O2	430	0.58		Antioxidant and Antimicrobial activity; Analgesic,; Antidiabatic; Antiinflammatory,; Antidermatitic,; Antileukemic,; Antitumor,; Anticancer,; Hepatoprotective, Antispasmodic
33	44.454	alpha.-Tocopherol	C29H50O2	430	0.26		Anti-inflammatory, antioxidant, antimicrobial, radical scavenging, antispasmodic

∗∗Source: Dr. Duke’s: Phytochemical and Ethnobotanical Databases.