Proteomic Identification of Altered Cerebral Proteins in the Complex Regional Pain Syndrome Animal Model

Table 6

Cerebral proteins with increased expression in the chronic postischemia pain (CPIP) group.

Number	Symbol	Description	value
1	Itpr2	Inositol 1,4,5-trisphosphate receptor type 2	0.001
2	Pik3r4	Phosphoinositide 3-kinase regulatory subunit 4	0.001
3	Exoc7	Exocyst complex component 7	0.001
4	Rcor2	REST corepressor 2	0.001
5	Anp32b	Acidic leucine-rich nuclear phosphoprotein 32 family member B	0.002
6	Qrich2	Glutamine rich 2-like	0.002
7	Dnah11	Dynein, axonemal, heavy chain 11	0.002
8	Plk1	Serine/threonine-protein kinase PLK1	0.004
9	Ephx1	Epoxide hydrolase 1	0.004
10	Cacnb3	Voltage-dependent L-type calcium channel subunit beta-3	0.004
11	Anxa1	Annexin A1	0.004
12	Tns1	Tensin 1	0.004
13	Hdac4	Histone deacetylase 4	0.004
14	Osbpl7	Oxysterol binding protein like 7	0.004
15	Ecsit	Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial	0.004
16	Sorbs3	Sorbin and SH3 domain containing 3, isoform CRA_b	0.004
17	Kctd12	Potassium channel tetramerisation domain containing 12	0.004
18	Ccbp2	Chemokine-binding protein 2	0.004
19	Drg2	Developmentally regulated GTP binding protein 2-like	0.004
20	Grid2	Glutamate receptor delta-2 subunit	0.004
21	Safb	Scaffold attachment factor B1	0.008
22	Dnm3	Isoform 1 of Dynamin-3	0.008
23	Dnajc16	DnaJ homolog subfamily C member 16	0.008
24	Sntb2	Syntrophin, beta 2	0.008
25	Pnpt1	Polyribonucleotide nucleotidyltransferase 1	0.008
26	Eif3g	Eukaryotic translation initiation factor 3 subunit G	0.008
27	Pole2	Polymerase (DNA directed), epsilon 2	0.008
28	Scyl1	N-terminal kinase-like protein	0.008
29	Atad1	ATPase family, AAA domain containing	0.008
30	Krt4	Keratin, type II cytoskeletal 4	0.008
31	Ctsa	Protective protein for beta-galactosidase	0.008
32	Abca1	5 ATP-binding cassette, subfamily A (ABC1), member 15	0.008
33	Dmwd	Dystrophia myotonica-containing WD repeat motif	0.008
34	Baiap3	BAI1-associated protein 3-like isoform 2	0.008
35	Znf512b	Uridine kinase-like 1	0.008
36	Gale	Gale protein	0.008
37	Pick1	PRKCA-binding protein	0.008
38	Acin1	Acin1 protein	0.008
39	Chid1	Chitinase domain containing 1	0.008
40	Pcyox1l	Pcyox1l protein	0.008
41	Rabl2b	RAB, member of RAS oncogene family-like 2B	0.008
42	Serpina3k	Serine protease inhibitor A3K	0.008
43	Glg1	Golgi apparatus protein 1	0.008
44	Tnc	Tenascin C	0.008
45	Lysmd1	LysM and putative peptidoglycan-binding domain-containing protein 1	0.008
46	Apba1	Amyloid beta A4 precursor protein-binding family A member 1	0.008
47	Ckap5	Cytoskeleton associated protein 5	0.038
48	Ndufab1	Acyl carrier protein	0.035
49	Epha4	Eph receptor A4	0.035
50	Kalrn	Isoform 2 of Kalirin	0.035
51	Myh14	Myosin, heavy chain 14	0.035
52	Anxa2	Isoform Short of Annexin A2	0.043
53	Ccdc47	Coiled-coil domain-containing protein 47	0.043
54	Gpr158	G protein-coupled receptor 158	0.042
55	Cugbp1	CUGBP Elav-like family member 1	0.041
56	Hba2	Hemoglobin alpha 2 chain	0.040
57	Acsl3	Isoform long of long-chain-fatty-acid-CoA ligase 3	0.040
58	Rab6a	Ras-related protein Rab-6A	0.038
59	Hbb	Hemoglobin subunit beta-1	0.048
60	Hbb-b1	Zero beta-1 globin	0.044
61	Khsrp	Far upstream element-binding protein 2	0.043
62	Scamp5	Secretory carrier-associated membrane protein 5	0.048
63	Aldh3a2	Fatty aldehyde dehydrogenase	0.049
64	Mesdc2	LDLR chaperone MESD	0.049
65	Rab3d	GTP-binding protein Rab-3D	0.051
66	Vps29	Isoform 2 of vacuolar protein sorting-associated protein 29	0.051
67	Psma3l	Psma3 Proteasome subunit alpha type-3	0.053
68	Hgs	Isoform 1 of hepatocyte growth factor-regulated tyrosine kinase	0.054
69	Nlgn3	Isoform 1 of neuroligin-3	0.056
70	Cygb	Cytoglobin	0.060
71	Pcsk2	Neuroendocrine convertase 2	0.060
72	Prkcd	Isoform 1 of Protein kinase C delta	0.060
73	Fnbp4	Formin binding protein 4	0.062
74	Eif2s3x	Eukaryotic translation initiation factor 2 subunit 3	0.063
75	Fermt2	Fermitin family homolog 2	0.063
76	Vps33a	Vacuolar protein sorting-associated protein 33A	0.063
77	SNX3	Sorting nexin-3	0.063
78	Exoc8	Exocyst complex component 8	0.063
79	Thrap3	Thyroid hormone receptor-associated protein 3	0.063
80	Ndufa1	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1	0.063
81	Gabarapl2	Gamma-aminobutyric acid receptor-associated protein-like 2	0.065
82	Cotl1	Coactosin-like protein	0.065
83	Gad1	Glutamate decarboxylase 1	0.065
84	Ehd1	EH domain-containing protein 1	0.066
85	Map2k4	Mitogen-activated protein kinase 4	0.066
86	Mug1	Murinoglobulin (alpha-1-inhibitor 3)	0.070
87	Pck2	Phosphoenolpyruvate carboxykinase 2	0.072
88	Rps5	40S ribosomal protein S5	0.072
89	Ap2s1	Adaptor protein complex 2 subunit sigma	0.075
90	Tpp1	Tripeptidyl-peptidase 1	0.076
91	Cyld	Ubiquitin carboxyl-terminal hydrolase	0.076
92	Nuc	Nucleolin-like protein	0.079
93	Col1a2	Collagen alpha-2(I) chain	0.079
94	Slc6a17	Orphan sodium- and chloride-dependent neurotransmitter transporter NTT4	0.079
95	Actr10	Actin-related protein 10 homolog	0.080
96	Cacng2	Voltage-dependent calcium channel gamma-2 subunit	0.083
97	Ampd3	AMP deaminase 3	0.083
98	Eif5b-ps1	Eif5b Eukaryotic translation initiation factor 5B	0.083
99	Timm9	Mitochondrial import inner membrane translocase subunit Tim9	0.083
100	Etl4	Enhancer trap locus 4-like	0.083
101	Csnk2a2	Casein kinase 2, alpha prime polypeptide	0.084
102	Cct6a	Chaperonin containing TCP1 subunit 6a	0.084
103	Nudc	Nuclear migration protein nud	0.085
104	Ndufa13	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 13	0.085
105	Camk2b	Calmodulin-dependent protein kinase II beta M isoform	0.086
106	Clta	Isoform brain of clathrin light chain A	0.086
107	Asah1	Acid ceramidase	0.086
108	Phb2	Prohibitin-2	0.086
109	Sod1	Superoxide dismutase [Cu-Zn]	0.088
110	Ndufs8	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 8	0.090
111	Slc17a7	Isoform 1 of vesicular glutamate transporter 1	0.091
112	Ugp2	UDP-glucose pyrophosphorylase 2, isoform CRA-b	0.091
113	Rala	Ras-related protein Ral-A	0.091
114	Anxa5	Annexin A5	0.093
115	Hnrph1	Isoform 1 of heterogeneous nuclear ribonucleoprotein H	0.093
116	Stxbp5l	Syntaxin binding protein 5-like	0.093
117	Abcd3	ATP-binding cassette subfamily D member 3	0.094
118	Farp1	FERM, RhoGEF (Arhgef), and pleckstrin domain protein 1	0.094
119	Leng4	Leng4 protein	0.094
120	Scn2a1	Sodium channel Nav1.2	0.095
121	Rab10	Ras-related protein Rab-10	0.097
122	Aldh7a1	Alpha-aminoadipic semialdehyde dehydrogenase	0.097
123	Cltb	Isoform Brain of Clathrin light chain B	0.097
124	Phyhipl	Isoform 1 of phytanoyl-CoA hydroxylase-interacting protein-like	0.098
125	Synpo	Isoform 1 of synaptopodin	0.099