MicroRNA Profiling Reveals Unique miRNA Signatures in IGF-1 Treated Embryonic Striatal Stem Cell Fate Decisions in Striatal Neurogenesis In Vitro

Table 1

miRNAs	value	Up-/downregulation	Predicted function in neurogenesis	mRNA targets	Functional; significance
miRNA503	0.003	1.35 times	transition of quiescence-to-proliferation stage	Cdk2/Cdc25A	[10]
miRNA433	0.002	1.68 times	Neural development; proliferation/self-renewal-to-differentiation	ERRG, NR0B2 or SHP-1, RISC, EIF2, Ago2, edaravone, and hydroxypropyl-beta-cyclodextrin	[11–13]
miRNA143	0.002	2.56 times	Proliferation, neural differentiation, and survival	PDGFRA, PRKCE, MAPK7, DSSP, DMP-1, KRAS, and BCL-2	[14, 15]
miRNA326	0.0002	1.58 times	Maintenance and survival of striatal precursor pool	TGM7	[16, 17]
miRNA181c	0.0029	1.50 times	Switch for; lineage-to-self-renewal and telomerase expression	PTPN11, PTPN22, DUSP6, PBX3, IRF8, and ZEB2	[18–21]
miRNA22	0.001	1.22 times	Proliferation and apoptosis	HDAC4, RCOR1, RGS2, MAPK14/p38, Tp53inp1, and P38 MAPK	[22, 23]