Enhanced Analgesic Properties and Reduced Ulcerogenic Effect of a Mononuclear Copper(II) Complex with Fenoprofen in Comparison to the Parent Drug: Promising Insights in the Treatment of Chronic Inflammatory Diseases
Figure 2
Effects of Fenoprofen calcium salt (21 mg kg−1) and [Cu(fen)2(im)2] (28 mg kg−1) on the acetic acid test. Both compounds were administered by oral gavage 1 hour before the acetic acid injection (i.p.). The number of writhing and stretching per mouse was counted over a 20-minute period. Values are expressed as means ± SEM; . and with respect to the control group administered with the vehicle. # with respect to the Fenoprofen group.
