Antioxidant and Prophylactic Effects of Delonix elata L., Stem Bark Extracts, and Flavonoid Isolated Quercetin against Carbon Tetrachloride-Induced Hepatotoxicity in Rats
Figure 5
Histopathology of liver tissues. (a) Liver section of normal control rats showing normal architecture; (b) Liver section of CCl4 treated rats showing massive fatty changes, cellular necrosis, vacuolization, and ballooning degeneration; (c) Liver section of rats treated with CCl4 and 100 mg kg−1 of DSC showing mild fatty vacuolation and cellular necrosis; (d) Liver section of rats treated with CCl4 and 300 mg kg−1 of DSC showing cellular regeneration, mild degree of cell necrosis, and fatty vacuolation; (e) Liver section of rats treated with CCl4 and 100 mg kg−1 of DSE showing few fatty vacuoles, restoration of hepatocytes, and lesser necrosis; (f) Liver section of rats treated with CCl4 and 300 mg kg−1 of DSE showing minimal inflammatory cellular infiltration and almost near normal liver architecture; (g) Liver section of rats treated with CCl4 and quercetin showing recovery from the toxic effect with normal arrangement of hepatocytes with little evidence of fatty vacuoles and cellular necrosis (h) Liver histology of animals treated with silymarin showing normal histology with least parenchymal injury. (1-cellular necrosis; 2-vacuolization; 3-ballooning degeneration).
