Antioxidant and Prophylactic Effects of Delonix elata L., Stem Bark Extracts, and Flavonoid Isolated Quercetin against Carbon Tetrachloride-Induced Hepatotoxicity in Rats
Table 5
Prophylactic effect of D. elata stem bark extracts and quercetin on restoration of liver function markers in CCl4 intoxicated rats.
Groups
ALP (U/L)
AST (U/L)
ALT (U/L)
Total Bilirubin (mg/dL)
Total Cholesterol (mg/dL)
Triglyceride (mg/dL)
Total protein (g/dL)
Control 1% DMSO
223.77 ± 5.85**
201.20 ± 3.84**
61.75 ± 3.34**
0.04 ± 0.01**
150.00 ± 2.00**
173.50 ± 2.75**
8.28 ± 0.15**
CCl4 (50%) 1 mL kg−1
400.10 ± 4.91
561.97 ± 9.64
161.90 ± 2.37
14.07 ± 1.04
274.00 ± 3.51
215.97 ± 5.48
5.84 ± 0.09
DSC 100 mg kg−1 + CCl4
346.3 ± 1.05**
413.84 ± 1.37**
127.02 ± 0.63**
0.09 ± 0.01**
250.60 ± 0.52**
199.28 ± 0.94ns
6.94 ± 0.20**
DSC 300 mg kg−1 + CCl4
308.50 ± 7.55**
356.60 ± 3.88**
107.70 ± 7.34**
0.076 ± 0.01**
225.00 ± 3.00**
197.70 ± 0.82ns
6.95 ± 0.27**
DSE 100 mg kg−1 + CCl4
332.08± 0.80**
390.94 ± 0.17**
110.98 ± 0.26**
0.07 ± 0.01**
212.30 ± 0.70**
189.44 ± 0.12**
7.12 ± 0.05**
DSE 300 mg kg−1 + CCl4
281.42 ± 6.28**
320.47 ± 3.58**
89.93 ± 10.94**
0.05 ± 0.01**
186.00 ± 3.21**
176.93 ± 1.65**
7.22 ± 0.19**
Quercetin 20 mg kg−1 + CCl4
281.37 ± 1.47**
330.56 ± 2.0**
97.81 ± 3.5**
0.05 ± 0.01**
192 ± 1.03**
181. 21 ± 2.31**
7.4 ± 0.22**
Silymarin 25 mg kg−1 + CCl4
241.87 ± 1.88**
316.13 ± 5.98**
84.63 ± 2.26**
0.03 ± 0.01**
186.00 ± 3.06**
162.23 ± 1.12**
7.86 ± 0.16**
Each value represents mean ± S.E.M. of 6 animals. Symbols represent statistical significance. and ns-not significant as compared to CCl4 toxic control.
