Antioxidant and Prophylactic Effects of Delonix elata L., Stem Bark Extracts, and Flavonoid Isolated Quercetin against Carbon Tetrachloride-Induced Hepatotoxicity in Rats
Table 6
Effect of stem bark extracts and quercetin on antioxidant liver markers in CCl4 intoxicated rats.
Groups
GPx (nmol NADPH min−1 mg−1 protein)
GST (nmol min−1 mg−1 of protein)
CAT (nmol min−1 mg−1 of protein)
SOD (Umg−1 of protein)
MDA (nmol mg−1 of protein)
Control 1% DMSO
163.72 ± 0.19**
422.7 ± 1.9**
484.82 ± 3.17**
12.47 ± 0.38**
0.64 ± 0.01**
CCl4 (50%) 1 mL kg−1
87.14 ± 0.35
209.58 ± 1.0
214.6 ± 0.7
5.16 ± 0.07
1.11 ± 0.01
DSC 100 mg kg−1 + CCl4
94.38 ± 0.29ns
295 ± 0.11**
253.02 ± 1.42**
6.36 ± 0.02**
0.92 ± 0.01**
DSC 300 mg kg−1 + CCl4
106.51 ± 0.81**
312.5 ± 1.74**
289.34 ± 0.33**
6.68 ± 0.03**
0.85 ± 0.01**
DSE 100 mg kg−1 + CCl4
104.65 ± 0.15*
304.44 ± 2.17**
306.22 ± 1.89**
7.17 ± 0.06**
0.83 ± 0.01**
DSE 300 mg kg−1 + CCl4
137.94 ± 0.44**
337.15 ± 0.45**
364.55 ± 0.45**
7.91 ± 0.01**
0.66 ± 0.01**
Quercetin 20 mg kg−1 + CCl4
134.47 ± 0.22**
340.58 ± 0.37**
348.80 ± 2.12**
7.63 ± 0.1**
0.64 ± 0.01**
Silymarin 25 mg kg−1 + CCl4
140.14 ± 1.11**
362.2 ± 1.0**
362.85 ± 0.05**
8.73 ± 0.14**
0.64 ± 0.01**
Each value represents mean ± S.E.M. of 6 animals. Symbols represent statistical significance. and ns-not significant as compared to CCl4 toxic control.
