BAG3 and HIF-1α Coexpression Detected by Immunohistochemistry Correlated with Prognosis in Hepatocellular Carcinoma after Liver Transplantation

Table 1

Relationship between BAG3/HIF-1α expression and clinicopathologic features.

Variable	BAG3 density		𝑃 value	HIF-1α density		𝑃 value
	Low-BAG3	High-BAG3		Low-HIF-1α	High-HIF-1α
In general
Tumor tissue	14	17		13	18
Sex
Male	12	16	0.425	12	16	0.624
Female	2	1		1	2
Age (years)
≦50	8	9	0.551	9	8	0.158
>50	6	8		4	10
Tumor size (cm)
≦5	9	4	𝟎.𝟎𝟐𝟕^∗	7	6	0.22
>5	5	13		6	12
AFP (ng/mL)
≦400	8	12	0.343	8	12	0.343
>400	6	5		5	6
HBsAg
Positive	12	14	0.597	12	14	0.285
Negative	2	3		1	4
Anti-HCV
Positive	1	1	0.708	1	1	0.671
Negative	13	16		12	17
Vascular invasion
Yes	6	12	0.117	6	12	0.22
No	8	5		7	6
TNM stage
I-II	10	3	𝟎.𝟎𝟎𝟒^∗	9	4	𝟎.𝟎𝟏𝟐^∗
III-IV	4	14		4	14
Tumor differentiation
I-II	2	3	0.597	2	3	0.659
III-IV	12	14		11	15
TACE or RFA using before LT
Yes	5	7	0.525	4	8	0.347
No	9	10		9	10
Rapamycin using after LT
Yes	2	4	0.429	2	4	0.501
No	12	13		11	14

AFP: α-fetoprotein. TACE: transcatheter arterial chemoembolization. RFA: radiofrequency ablation.
^∗𝑃<0.05.