|
| MRS technique | Number of PD patients | Main results versus control subjects | Mean (SD) of metabolite ratios in controls | Mean (SD) of metabolite ratios in PD patients | Significant differences were indicated by the following: | Reference |
|
|
1HMRS at 1.5 T | 6 | Reduction of NAA/Cho ratios in the lentiform nucleus | NAA/Cho:
2.11 (0.39) | NAA/Cho:
1.29 (0.28) | . | [9] |
|
|
1HMRS at 1.5 T | 15 (in 7 the symptomatic side was on the left and in 8 it was on the right) | Reduction of NAA/Cr ratios in the left symptomatic side of SN | NAA/Cr:
1.37 (0.22) | NAA/Cr:
1.20 (0.36) | | [10] |
|
|
1HMRS at 1.5 T | 10 | Increase of total Cr in the prefrontal cortex | Cr:
0.61 (0.16) IU | Cr:
0.76 (0.08) IU | | [11] |
|
|
1HMRS at 1.5 T | 20 | Reduction of NAA/Cr and Cho/Cr ratios in the temporoparietal cortex | NAA/Cr:
2.06 (*)
Cho/Cr:
0.75 (*) | NAA/Cr:
1.78 (*)
Cho/Cr:
0.47 (*) | For NAA/Cr
For Cho/Cr
| [12] |
|
|
1HMRS at 1.5 T | 17 | Reduction of NAA/Cr ratios in the temporoparietal cortex | NAA/Cr:
2.20 (0.38) | NAA/Cr:
1.78 (0.30) | | [13] |
|
|
1HMRS at 1.5 T | 10 | Reduction of NAA/Cr ratios in the motor cortex | NAA/Cr:
1.34 (0.11) | NAA/Cr:
1.21 (0.12) | | [14] |
|
|
1HMRS at 1.5 T | 12 | Reduction of NAA/Cr ratios in the posterior cingulated cortex | NAA/Cr:
1.78 (0.39) | NAA/Cr:
1.53 (0.20) | | [15] |
|
|
1HMRS at 1.5 T | 44 | Reduction of NAA/Cr ratios in the presupplementary motor area | NAA/Cr:
1.47 (0.16) | NAA/Cr:
1.39 (0.17) | | [16] |
|
| 3D 1HMRSI at 3 T | 9 | Reduction of NAA/Cr and mI/Cr in the rostral SN regions and increase of NAA/Cr and mI/Cr in the caudal SN regions | NAA/Crros:
3.34 (1.23)
mI/Crros:
0.82 (0.43)
NAA/Crcau:
2.03 (0.67)
mI/Crcau:
0.64 (0.34) | NAA/Crros:
2.45 (1.55)
mI/Crros:
0.59 (0.52)
NAA/Crcau:
4.92 (2.96)
mI/Crcau:
1.95 (1.43) | for NAA/Crros
for
mI/Crros
for NAA/Crcau
for
mI/Crcau | [21] |
|
|
1HMRSI at 3 T | 20 | Reduction of NAA/Cr and Cho/Cr ratios in bilateral temporal gray matter and increase of total Cr in the right temporal gray matter | NAA/Crleft:
1.27 (0.09)
Cho/Crleft:
0.18 (0.032)
NAA/Crrigth:
1.32 (0.121)
Cho/Crleft:
0.18 (0.034)
Crrigth:
1995 (225) IU | NAA/Crleft:
1.13 (0.131)
Cho/Crleft:
0.14 (0.028)
NAA/Crrigth:
1.17 (0.213)
Cho/Crleft:
0.13 (0.034)
Crrigth:
2243 (361) IU | for NAA/Crleft and Cho/Crleft
for NAA/Crright
for Cho/Crright
for Crright | [22] |
|
|
1HMRS at 3 T | 12 | Reduction of Glu/Cr ratios in the posterior cingulated gyrus | Glu/Cr:
0.555 (0.07) | Glu/Cr:
0.474 (0.092) | | [23] |
|
|
1HMRS at 4 T | 10 | Reduction of Glu, NAA, and glutathione and increase of Cho in the SN. Increase of GABA/Glu ratio in SN versus cerebral cortex | NA | NA | NA | [24] |
|
|
1HMRS at 7 T | 13 | Increase of GABA in the pons and putamen | GABApons:
1.0 (0.2) mol/g
GABAputamen:
1.6 (0.2) mol/g | GABApons:
1.6 (0.4) mol/g
GABAputamen:
2.1 (0.4) mol/g | for GABApons
for GABAputamen | [25] |
|
