|
| MRS technique | Disease | Main results | Mean (SD) of metabolite ratios in controls | Mean (SD) of metabolite ratios in patients | Significant differences were indicated by the following: | Reference |
|
1HMRS
at 1.5 T | MSA-P and PD versus controls | Reduction of NAA/Cr ratios in the lentiform nucleus | NAA/Cr:
1.76 (0.96) | NAA/CrMSA-P:
1.35 (0.29)
NAA/CrPD:
1.82 (0.28) | MSA-P versus controls PD versus controls | [17] |
|
1HMRS
at 1.5 T | PSP, CBD, MSA, and VP versus controls | Reduction of NAA/Cr ratios in the more affected frontal cortex | NAA/Cr:
2.1 (0.2) | NAA/CrPSP: 1.4 (0.5)
NAA/CrCBD: 0.9 (0.4)
NAA/CrMSA: 1.2 (0.2)
NAA/CrVP: 1.7 (0.1) | PSP, MSA and
VP versus controls; CBD versus controls |
[37] |
| PSP, MSA, CBD, and PD versus controls | Reduction of NAA/Cr ratios in the more affected putamen | NAA/Cr:
2.2 (0.2) | NAA/CrPSP: 1.4 (0.2)
NAA/CrCBD: 1.0 (0.4)
NAA/CrMSA: 1.8 (0.3)
NAA/CrPD: 1.5 (0.2) | PSP and PD versus controls;
CBD versus controls;
MSA versus controls |
|
| | | Reduction of NAA levels in the putamen | NAA:
7.1 (1.6) mM | NAAPSP: 5.26 (0.9) mM
NAAMSA-P: 5.27 (0.6) mM
NAAPD: 6.88 (1.2) mM | MSA-P versus controls
MSA-P versus PD
PSP versus controls
PSP versus PD | |
1HMRS
at 1.5 T | MSA-P and PSP versus controls and PD | Reduction of NAA levels in the pallidum | NAA:
6.52 (1.5) mM | NAAPSP: 4.07 (1.0) mM
NAAMSA-P: 5.54 (1.1) mM
NAAPD: 6.36 (0.8) mM | PSP versus controls
PSP versus PD | [38] |
| | | Reduction of NAA levels in the lentiform nucleus | NAA:
6.77 (1.2) mM | NAAPSP: 4.6 (0.6) mM
NAAMSA-P: 5.4 (0.7) mM
NAAPD: 6.62 (0.8) mM | MSA-P versus controls
MSA-P versus versus PD
PSP versus controls
PSP versus PD | |
|
1HMRS
at 1.5 T | MSA and PSP versus controls and PD | Reduction of NAA/Cho ratios in the lentiform nucleus | NAA/Cho:
2.02 (0.43) | NAA/ChoMSA:
1.39 (0.31)
NAA/ChoPSP:
1.45 (0.28)
NAA/ChoPD:
1.82 (0.28) | MSA versus controls
PSP versus controls
MSA versus PD
PSP versus PD |
[39] |
1HMRS
at 1.5 T | MSA, PSP, and PD versus controls and MSA versus PD | Reduction of NAA/Cr ratios in the lentiform nucleus | NAA/Cr:
1.86 (0.29) | NAA/CrMSA:
1.32 (0.30)
NAA/CrPSP:
1.40 (0.17)
NAA/CrPD:
1.65 (0.41) | MSA versus controls
PSP versus controls
PD versus controls MSA versus PD |
|
|
1HMRS at 3 T | MSA-C and MSA-P versus controls; MSA-P versus PD | Reduction of NAA/Cr ratios in the pontine basis | NA | NA | MSA-C versus controls
MSA-P versus controls
MSA-P versus PD |
[40] |
| MSA-P versus controls and PD | Reduction of NAA/Cr ratios in the putamen | NA | NA | MSA-P versus controls
MSA-P versus PD |
|
|
3D 1HMRSI at 3 T | PD versus controls and ADPs | Lower NAA/Cr ratios in the rostral SN regions than those in the caudal SN regions | (NAA/Cr)ros: 2.56 (0.73) and
(NAA/Cr)cau: 1.85 (0.51) | In PD (NAA/Cr)ros: 1.97 (1.24) and
(NAA/Cr)cau: 3.47 (2.37).
In ADPs (NAA/Cr)ros: 2.29 (1.37) and
(NAA/Cr)cau: 2.09 (0.92) | PD versus controls; PD versus APDs |
[41] |
| APDs versus controls | Lower NAA/Cr ratios in the caudal SN regions than those in the rostral SN regions | (NAA/Cr)ros: 2.56 (0.73) and
(NAA/Cr)cau: 1.85 (0.51) | (NAA/Cr)ros: 2.29 (1.37) and
(NAA/Cr)cau: 2.09 (0.92) | APDs versus controls |
|
