Table 1: Frequency of potential XREs boxes in the upstream sequences of selected inflammatory response-related genes.

Innate immunityAdaptive immunity
GeneXREs frequencyGeneXREs frequency

Il6 3Il2 3
Il18 10Il4 2
TNFα1Il12a 3
Il17 3
Il1r1 5Il17c 6
Il1r2 7Il21 4
Il1rap 12Il23a 5
Il18rap 1
Il2rb 7
Tlr1 5Il2rg 5
Tlr2 2Il4ra 9
Tlr3 3Il12rb1 4
Tlr4 5Il17r 6
Tlr5 9Il17rb 3
Tlr6 3Il17rd 7
Tlr7 4Il17re 6
Tlr8 2Ifngr 11
Tlr9 3Ifngr2 5
Irak1 5Jak1 5
Irak4 4Jak2 9
Traf6 5Jak3 20
C3ar 5Stat1 9
Il6st 2Stat3 5
Kit 11Stat5a 9
Il18bp 1Stat5b 7
Lifat 7Irf1 6

The genes are selected from [62].