MicroRNA: Important Player in the Pathobiology of Multiple Myeloma

Figure 2

miRNA and p53 in MM. P53 can be directly targeted by miR-125b, miR-25, and miR-30d and indirectly targeted by miR-106b∼25 cluster, miR-32, miR-181a which target PCAF, a positive regulator of p53. Upregulation of these miRNAs in MM were observed in multiple studies. On the other hand, p53 transcriptionally induces miRs-192, -194, and -215 which target MDM2 and miR-34a which target SIRT1. Both pathways lead to upregulation of p53, forming two positive feedback loops. Deregulation of these miRNAs leads to compromised p53 tumor suppressor pathway and favors oncogenesis.