Hydrophobic Substituents of the Phenylmethylsulfamide Moiety Can Be Used for the Development of New Selective Carbonic Anhydrase Inhibitors

Table 1

hCAs I, II, IX, and XII inhibition data with sulfamides 11–16. Acetazolamide (AAZ) has been used as standard drug. Analyses were performed with a CO₂ hydrase, stopped-flow assay [41].

Compounds	(nM)*
	hCA I	hCA II	hCA IX	hCA XII
11	2180	74.1	40.7	5.8
12	4050	134	60.0	6.6
13	1940	9.8	59.1	8.4
14	1810	9.5	61.7	8.1
15	1650	188	56.3	6.5
16	1440	43.3	62.1	6.6
AAZ	250	12	25	5.7

*Mean from 3 different assays, errors in the range of ±10% of the reported values.