The Association between Autoantibodies and Peripheral Neuropathy in Lupus Nephritis

Table 1

Clinical and laboratory data of lupus nephritis with or without peripheral neuropathy.

	SLE-LN with neuropathy; (𝑛=15)	SLE-LN without neuropathy; (𝑛=544)	𝑃 value
Age	48.93±15.02	41.5±16.5	0.073
Male/female	0/15	16/528	ND
Classification of peripheral neuropathy^§
Autonomic neuropathy	4	0	ND
Mixed sensory-motor polyneuropathy	13	0	ND
Sensory polyneuropathy	2	0	ND
Autoantibody titers, median (IQR)
Anti-β2 glycoprotein I	5.7 (2.65–6.25)	3.8 (2.4–5.6)	0382
Anti-cardiolipin IgG	21.6 (7.68–26.7)	6.5 (3.3–15.0)	0.071
Anti-cardiolipin IgM	3.8 (0.75–49.3)	2.2 (1.2–4.5)	0.429
Anti-Ro	240 (106–240.0)	92.3 (0.9–240.0)	0.009*
Anti-La	1.9 (1–51.4)	1.1 (0.4–6.3)	0.095
Anti-RNP	26.7 (2.3–77.9)	2.5 (1.4–27.9)	0.078
anti-Smith IgG	1.4 (0.5–2.9)	0.6 (0.3–2.7)	0.15
Anti-scl-70	0.35 (0.18–0.63)	0.4 (0.2–0.6)	0.699
Anti-Jo1	0.5 (0.1–0.5)	0.2 (0.1–0.5)	0.459
Anti-centromere IgG	0.5 (0.2–1.0)	0.5 (0.2–1.0)	0.457
p-ANCA	0.9 (0.6–2.1)	0.9 (0.5–1.4)	0.804
c-ANCA	1.1 (0.48–1.43)	0.9 (0.5–1.4)	0.855

§Four patients had both polyneuropathy and autonomic neuropathy.
SLE-LN: systemic lupus erythematosus with lupus nephritis; p-ANCA: peri-nuclear anti-neutrophil cytoplasmic antibody; c-ANCA: cytoplasmic anti-neutrophil cytoplasmic antibody; IQR: interquartile range; CI: confidence interval; ND: not done.
∗𝑃<0.05.