Review Article
Blood Biomarkers for Amyotrophic Lateral Sclerosis: Myth or Reality?
Table 4
Blood biomarkers related to neurodegeneration.
| Biomarker | ALS | Controls | Finding | Reference |
| Anti-Fas | 52 | 20H 22ND | High serum level in ALS subtype | [84] | Caspase-9 | 30 | 30ND | High serum level Correlated with severity and duration | [83] | Cystatin C | 44 | 35H 25ND | High plasma level | [85] | ICE/Caspase-1 | 25 | 15H | High serum level | [82] | NFL | 46 | 67H 97ND | High serum level | [86] | pNF-H | 62 | ā | Plasma and serum level correlated with ALSFRS-R decline | [89] | 71 | 40H 52ND | High plasma level | [88] | S100- | 41 | 32H | Serum level correlated with progression | [92] |
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H: healthy; ND: neurological/neurodegenerative disease; ALSFRS-R: revised ALS functional rating scale; ICE: interleukin-1 converting enzyme; NFL: neurofilament light chain; pNF-H: phosphorylated neurofilament heavy chain.
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