Patched Targeting Peptides for Imaging and Treatment of Hedgehog Positive Breast Tumors
Figure 2
Patched-binding peptides have significant uptake in breast cancer cell lines. (a) Fluorescence microscopy of FITC-labeled peptides A and B in SKBR3 breast cancer cells. (b) Quantification of FITC-peptides A and B uptake in breast cancer cell lines. (c) Fluorescence microscopy of SKBR3 cells showing colocalization of peptide B (green) with the PTCH receptor (red). Colocalization appears as yellow staining in the image overlay.
