Short-Term Esmolol Improves Coronary Artery Remodeling in Spontaneously Hypertensive Rats through Increased Nitric Oxide Bioavailability and Superoxide Dismutase Activity

Figure 1

Structural parameters. (a) External diameter, (b) lumen diameter, (c) wall thickness, (d) wall-to-lumen ratio, and (e) media cross-sectional area of intramyocardial artery of the left ventricle from Wistar Kyoto control rats (WKY, 𝑛=5), spontaneously hypertensive control rats (SHR, 𝑛=5), and spontaneously hypertensive rats treated with esmolol (SHR-E, 𝑛=5). Data are expressed as mean ±SEM. Statistically significant differences between WKY, SHR, and SHR-E are shown (^∗𝑃<0.05 versus WKY; ^∗∗𝑃<0.01 versus WKY; ^∗∗∗𝑃<0.001 versus WKY; ^#𝑃<0.05 versus SHR; ^##𝑃<0.01 versus SHR; ^###𝑃<0.001 versus SHR).

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