Short-Term Esmolol Improves Coronary Artery Remodeling in Spontaneously Hypertensive Rats through Increased Nitric Oxide Bioavailability and Superoxide Dismutase Activity
Figure 3
Vascular reactivity parameters. (a) acetylcholine (ACh) responses and (b) sodium nitroprusside (SNP) in left anterior descending artery precontracted with 5-hydroxytryptamine (5-HT, 3 × 10−7 mol/l) from Wistar Kyoto control rats (WKY, ), spontaneously hypertensive control rats (SHR, ), and spontaneously hypertensive rat treated with esmolol (SHR-E, ). Relaxing responses are expressed as percentage reduction in the 5-HT preconstricted state. Data are expressed as mean ± SEM. Statistically significant differences between WKY, SHR, and SHR-E are shown ( versus WKY; versus WKY; versus SHR).
